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Description:
DNA mismatch repair protein MSH3 (AtMsh3).
Molecular weight: 1193
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
07-MAR-2006, entry version 38.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH3_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ007791 | CAA07684.1 | - |
| EMBL | AL022197 | CAA18172.1 | - |
| PIR | T05793 | T05793. | |
| PIR | T51613 | T51613. | |
| HSSP | Q56215 | 1EWR | |
| GenomeReviews | CT486007_GR | AT4G25540.1 | |
| TAIR | At4g25540 | -.1 | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RX MEDLINE=99444907; PubMed=10517319; DOI=10.1007/s004380051080;
RA Ade J., Belzile F., Philippe H., Doutriaux M.P.;
RT "Four mismatch repair paralogues coexist in Arabidopsis thaliana:
RT AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2.";
RL Mol. Gen. Genet. 262:239-249(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20083488; PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA Van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA Van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT thaliana.";
RL Nature 402:769-777(1999).
Feature:
CHAIN 1 1081 DNA mismatch repair protein MSH3.
/FTId=PRO_0000115194.
NP_BIND 817 824 ATP (Potential).
CONFLICT 159 176 SVPTFRLNFHVRRLVNAG -> R (in Ref. 2).
CONFLICT 548 548 E -> EVKIWPVLCPLMYVPVSSSPGLRVLNFLDEK (in
Ref. 2).
CONFLICT 878 896 SEASHIIRTCSSRSLVILD -> N (in Ref. 2).
Comments:
-!- FUNCTION: Not known. Probable DNA-repair protein.
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 1081
MGKQKQQTIS RFFAPKPKSP THEPNPVAES STPPPKISAT VSFSPSKRKL LSDHLAAASP
KKPKLSPHTQ NPVPDPNLHQ RFLQRFLEPS PEEYVPETSS SRKYTPLEQQ VVELKSKYPD
VVLMVEVGYR YRFFGEDAEI AARVLGIYAH MDHNFMTASV PTFRLNFHVR RLVNAGYKIG
VVKQTETAAI KSHGANRTGP FFRGLSALYT KATLEAAEDI SGGCGGEEGF GSQSNFLVCV
VDERVKSETL GCGIEMSFDV RVGVVGVEIS TGEVVYEEFN DNFMRSGLEA VILSLSPAEL
LLGQPLSQQT EKFLVAHAGP TSNVRVERAS LDCFSNGNAV DEVISLCEKI SAGNLEDDKE
MKLEAAEKGM SCLTVHTIMN MPHLTVQALA LTFCHLKQFG FERILYQGAS FRSLSSNTEM
TLSANTLQQL EVVKNNSDGS ESGSLFHNMN HTLTVYGSRL LRHWVTHPLC DRNLISARLD
AVSEISACMG SHSSSQLSSE LVEEGSERAI VSPEFYLVLS SVLTAMSRSS DIQRGITRIF
HRTAKATEFI AVMEAILLAG KQIQRLGIKQ DSEMRSMQSA TVRSTLLRKL ISVISSPVVV
DNAGKLLSAL NKEAAVRGDL LDILITSSDQ FPELAEARQA VLVIREKLDS SIASFRKKLA
IRNLEFLQVS GITHLIELPV DSKVPMNWVK VNSTKKTIRY HPPEIVAGLD ELALATEHLA
IVNRASWDSF LKSFSRYYTD FKAAVQALAA LDCLHSLSTL SRNKNYVRPE FVDDCEPVEI
NIQSGRHPVL ETILQDNFVP NDTILHAEGE YCQIITGPNM GGKSCYIRQV ALISIMAQVG
SFVPASFAKL HVLDGVFTRM GASDSIQHGR STFLEELSEA SHIIRTCSSR SLVILDELGR
GTSTHDGVAI AYATLQHLLA EKRCLVLFVT HYPEIAEISN GFPGSVGTYH VSYLTLQKDK
GSYDHDDVTY LYKLVRGLCS RSFGFKVAQL AQIPPSCIRR AISMAAKLEA EVRARERNTR
MGEPEGHEEP RGAEESISAL GDLFADLKFA LSEEDPWKAF EFLKHAWKIA GKIRLKPTCS
F