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Description:
DNA mismatch repair protein MSH6-1 (AtMsh6-1).
Molecular weight: 1467
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 2.
07-MAR-2006, entry version 41.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH6_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF001535 | AAB57798.1 | - |
| EMBL | AJ245967 | CAB53337.1 | - |
| EMBL | AF001308 | AAC78699.1 | - |
| EMBL | AL161493 | CAB80700.1 | - |
| PIR | T01508 | T01508. | |
| HSSP | P23909 | 1OH6 | |
| GenomeReviews | CT486007_GR | AT4G02070.1 | |
| TAIR | At4g02070 | -.1 | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| InterPro | IPR002999 | Tudor. | |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| SMART | SM00333 | TUDOR | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Landsberg erecta;
RA Till S., Granat S., Parnell L., Kaplan N., Hoffman J., Lodhi M.,
RA Johnson A.F., Dedhia N., Martienssen R., McCombie W.R.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=99444907; PubMed=10517319; DOI=10.1007/s004380051080;
RA Ade J., Belzile F., Philippe H., Doutriaux M.P.;
RT "Four mismatch repair paralogues coexist in Arabidopsis thaliana:
RT AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2.";
RL Mol. Gen. Genet. 262:239-249(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20083488; PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
RA Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
RA Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
RA Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
RA Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
RA Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
RA Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
RA Langham S.-A., McCullagh B., Bilham L., Robben J.,
RA Van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
RA Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
RA Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
RA Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
RA De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
RA Van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
RA Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
RA Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
RA Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
RA Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
RA Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
RA Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
RA Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
RA Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
RA Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
RA Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
RA Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
RA Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
RA Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
RA Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
RA Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
RA Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
RA Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
RA Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
RA Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
RA Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
RA Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
RA Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
RA Chen E., Marra M.A., Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis
RT thaliana.";
RL Nature 402:769-777(1999).
Feature:
CHAIN 1 1324 DNA mismatch repair protein MSH6-1.
/FTId=PRO_0000115210.
NP_BIND 1083 1090 ATP (Potential).
CONFLICT 316 318 ADR -> GKPKSLLL (in Ref. 1).
CONFLICT 383 383 Q -> QVRRAHGNL (in Ref. 1).
CONFLICT 852 852 P -> PGIINLLHIHILILANCTASHIISLP (in Ref.
1).
Comments:
-!- FUNCTION: Involved in post-replicative DNA-mismatch repair (By
similarity).
-!- SUBUNIT: Heterodimer of MSH2 and MSH6 (GTBP) (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 1324
MAPSRRQISG RSPLVNQQRQ ITSFFGKSAS SSSSPSPSPS PSLSNKKTPK SNNPNPKSPS
PSPSPPKKTP KLNPNPSSNL PARSPSPGPD TPSPVQSKFK KPLLVIGQTP SPPQSVVITY
GDEVVGKQVR VYWPLDKKWY DGSVTFYDKG EGKHVVEYED GEEESLDLGK EKTEWVVGEK
SGDRFNRLKR GASALRKVVT DSDDDVEMGN VEEDKSDGDD SSDEDWGKNV GKEVCESEED
DVELVDENEM DEEELVEEKD EETSKVNRVS KTDSRKRKTS EVTKSGGEKK SKTDTGTILK
GFKASVVEPA KKIGQADRVV KGLEDNVLDG DALARFGARD SEKFRFLGVD RRDAKRRRPT
DENYDPRTLY LPPDFVKKLT GGQRQWWEFK AKHMDKVVFF KMGKFYELFE MDAHVGAKEL
DIQYMKGEQP HCGFPEKNFS VNIEKLVRKG YRVLVVEQTE TPDQLEQRRK ETGSKDKVVK
REVCAVVTKG TLTDGEMLLT NPDASYLMAL TEGGESLTNP TAEHNFGVCL VDVATQKIIL
GQFKDDQDCS ALSCLLSEMR PVEIIKPAKV LSYATERTIV RQTRNPLVNN LVPLSEFWDS
EKTIYEVGII YKRINCQPSS AYSSEGKILG DGSSFLPKML SELATEDKNG SLALSALGGA
IYYLRQAFLD ESLLRFAKFE SLPYCDFSNV NEKQHMVLDA AALENLEIFE NSRNGGYSGT
LYAQLNQCIT ASGKRLLKTW LARPLYNTEL IKERQDAVAI LRGENLPYSL EFRKSLSRLP
DMERLIARMF SSIEASGRNG DKVVLYEDTA KKQVQEFIST LRGCETMAEA CSSLRAILKH
DTSRRLLHLL TPGQSLPNIS SSIKYFKDAF DWVEAHNSGR VIPHEGADEE YDCACKTVEE
FESSLKKHLK EQRKLLGDAS INYVTVGKDE YLLEVPESLS GSVPHDYELC SSKKGVSRYW
TPTIKKLLKE LSQAKSEKES ALKSISQRLI GRFCEHQEKW RQLVSATAEL DVLISLAFAS
DSYEGVRCRP VISGSTSDGV PHLSATGLGH PVLRGDSLGR GSFVPNNVKI GGAEKASFIL
LTGPNMGGKS TLLRQVCLAV ILAQIGADVP AETFEVSPVD KICVRMGAKD HIMAGQSTFL
TELSETAVML TSATRNSLVV LDELGRGTAT SDGQAIAESV LEHFIEKVQC RGFFSTHYHR
LSVDYQTNPK VSLCHMACQI GEGIGGVEEV TFLYRLTPGA CPKSYGVNVA RLAGLPDYVL
QRAVIKSQEF EALYGKNHRK TDHKLAAMIK QIISSVASDS DYSASKDSLC ELHSMANTFL
RLTN