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Description:
DNA mismatch repair protein MSH6-2 (AtMsh6-2) (MutS homolog 7).
Molecular weight: 1222
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-MAR-2006, entry version 38.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH7_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ007792 | CAA07685.1 | - |
| EMBL | AF193018 | AAF06013.1 | - |
| EMBL | AB020746 | BAB01996.1 | - |
| EMBL | AF009657 | AAB82654.1 | - |
| HSSP | Q56215 | 1NNE | |
| GenomeReviews | BA000014_GR | AT3G24495.1 | |
| GeneFarm | 5083 | -.1 | |
| TAIR | At3g24495 | -.1 | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007695 | MutS_N. | |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RX MEDLINE=99444907; PubMed=10517319; DOI=10.1007/s004380051080;
RA Ade J., Belzile F., Philippe H., Doutriaux M.P.;
RT "Four mismatch repair paralogues coexist in Arabidopsis thaliana:
RT AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2.";
RL Mol. Gen. Genet. 262:239-249(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RX MEDLINE=20312761; PubMed=10852942; DOI=10.1105/tpc.12.6.991;
RA Culligan K.M., Hays J.B.;
RT "Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-
RT form three distinct protein heterodimers with different specificities
RT for mismatched DNA.";
RL Plant Cell 12:991-1002(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20363099; PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II.
RT Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC
RT and BAC clones.";
RL DNA Res. 7:217-221(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 852-937.
RC STRAIN=cv. Columbia;
RX MEDLINE=98002338; PubMed=9342879; DOI=10.1104/pp.115.2.833;
RA Culligan K.M., Hays J.B.;
RT "DNA mismatch repair in plants. An Arabidopsis thaliana gene that
RT predicts a protein belonging to the MSH2 subfamily of eukaryotic MutS
RT homologs.";
RL Plant Physiol. 115:833-839(1997).
Feature:
CHAIN 1 1109 DNA mismatch repair protein MSH6-2.
/FTId=PRO_0000115211.
NP_BIND 853 860 ATP (Potential).
CONFLICT 573 579 GPSGTLY -> VLQGPLN (in Ref. 2).
CONFLICT 583 583 D -> E (in Ref. 2).
Comments:
-!- FUNCTION: Involved in post-replicative DNA-mismatch repair (By
similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 1109
MQRQRSILSF FQKPTAATTK GLVSGDAASG GGGSGGPRFN VKEGDAKGDA SVRFAVSKSV
DEVRGTDTPP EKVPRRVLPS GFKPAESAGD ASSLFSNIMH KFVKVDDRDC SGERSREDVV
PLNDSSLCMK ANDVIPQFRS NNGKTQERNH AFSFSGRAEL RSVEDIGVDG DVPGPETPGM
RPRASRLKRV LEDEMTFKED KVPVLDSNKR LKMLQDPVCG EKKEVNEGTK FEWLESSRIR
DANRRRPDDP LYDRKTLHIP PDVFKKMSAS QKQYWSVKSE YMDIVLFFKV GKFYELYELD
AELGHKELDW KMTMSGVGKC RQVGISESGI DEAVQKLLAR GYKVGRIEQL ETSDQAKARG
ANTIIPRKLV QVLTPSTASE GNIGPDAVHL LAIKEIKMEL QKCSTVYGFA FVDCAALRFW
VGSISDDASC AALGALLMQV SPKEVLYDSK GLSREAQKAL RKYTLTGSTA VQLAPVPQVM
GDTDAAGVRN IIESNGYFKG SSESWNCAVD GLNECDVALS ALGELINHLS RLKLEDVLKH
GDIFPYQVYR GCLRIDGQTM VNLEIFNNSC DGGPSGTLYK YLDNCVSPTG KRLLRNWICH
PLKDVESINK RLDVVEEFTA NSESMQITGQ YLHKLPDLER LLGRIKSSVR SSASVLPALL
GKKVLKQRVK AFGQIVKGFR SGIDLLLALQ KESNMMSLLY KLCKLPILVG KSGLELFLSQ
FEAAIDSDFP NYQNQDVTDE NAETLTILIE LFIERATQWS EVIHTISCLD VLRSFAIAAS
LSAGSMARPV IFPESEATDQ NQKTKGPILK IQGLWHPFAV AADGQLPVPN DILLGEARRS
SGSIHPRSLL LTGPNMGGKS TLLRATCLAV IFAQLGCYVP CESCEISLVD TIFTRLGASD
RIMTGESTFL VECTETASVL QNATQDSLVI LDELGRGTST FDGYAIAYSV FRHLVEKVQC
RMLFATHYHP LTKEFASHPR VTSKHMACAF KSRSDYQPRG CDQDLVFLYR LTEGACPESY
GLQVALMAGI PNQVVETASG AAQAMKRSIG ENFKSSELRS EFSSLHEDWL KSLVGISRVA
HNNAPIGEDD YDTLFCLWHE IKSSYCVPK