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Description:
DNA cross-link repair protein SNM1 (AtSNM1).
Molecular weight: 55161
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 31.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein SNM1_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X97827 | CAA66406.1 | - |
| EMBL | X98130 | CAA66817.1 | - |
| EMBL | AB026648 | BAB01732.1 | - |
| EMBL | AK117422 | BAC42087.1 | - |
| EMBL | BT005000 | AAO50533.1 | - |
| GenomeReviews | BA000014_GR | AT3G26680.1 | |
| GeneFarm | 5058 | -.1 | |
| TAIR | At3g26680 | -.1 | |
| InterPro | IPR011084 | DRMBL. | |
| Pfam | PF07522 | DRMBL | 1. |
Keywords:
DNA damage; DNA repair; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Columbia; TISSUE=Shoot;
RX MEDLINE=97086699; PubMed=8932388; DOI=10.1093/nar/24.21.4313;
RA Quigley F., Dao P., Cottet A., Mache R.;
RT "Sequence analysis of an 81 kb contig from Arabidopsis thaliana
RT chromosome III.";
RL Nucleic Acids Res. 24:4313-4318(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20277480; PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=21932900; PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
RA Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
RA Shibata K., Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP FUNCTION, AND INDUCTION.
RX PubMed=15448639; DOI=10.1038/sj.embor.7400256;
RA Molinier J., Stamm M.-E., Hohn B.;
RT "SNM-dependent recombinational repair of oxidatively induced DNA
RT damage in Arabidopsis thaliana.";
RL EMBO Rep. 5:994-999(2004).
Feature:
CHAIN 1 484 DNA cross-link repair protein SNM1.
/FTId=PRO_0000209128.
CONFLICT 484 484 R -> P (in Ref. 1; CAA66406).
Comments:
-!- FUNCTION: May be required for repair of DNA lesions formed after
exposure to oxidative stress.
-!- SUBCELLULAR LOCATION: Nucleus (By similarity).
-!- INDUCTION: Induced by bleomycin, methyl methane sulphonate and
hydrogen peroxide, which are known to induce oxidative lesions in
DNA. Also induced by bacterial flagellin, which is known to elicit
plant defense responses and a rapid oxidative burst, and by
xylanase.
-!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase
(DRMBL) family.
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Sequence length: 484
MDFSDEDDDE NCFGSRFNDG VNEEEEDEEG FVFNDDVEEN EEEEGFASDF YKAGSDWSCL
VEDEETVSSS VKKMKQSNLF QIWGLQENSP DTTKKMKQTD LFQSWGLQKP SPFTSPASNS
AKKTTSALGK RRRDSSFSND SPRPCPFYKK LPGTPFTVDA FRYGCVQGCS AYFLTHFHAD
HYIGLTKAWS HGPIYCSSLT SRLLRLSLSV NPSSIHPLEL DVEYTINGIK VTLIEANHCP
GAALIHFRLL DGTCYLHTGD FRASKQMQTH PLLFNQRVHV LYLDTTYCNP RYKFPSKEDV
LSYVVRITKD FLRKQPKTLI VVGSYSIGKE CVYLAIAKAL GVKIFANASR RRILQSFGWD
DISKNLSTDG KATCLHVLPM SSLKVERLDE HLKIYREQYG AVLAFRPTGW TYSEKIGEHL
DLIKPTSRGK ITIYGVPYSE HSSFTELREF VQFLRPDKII PTVNNGNAGT REKMQSCFRE
WLRR