|
|
|
|
|
|
Description:
DNA-repair protein UVH3 (EC 3.1.-.-) (UV hypersensitive protein 3)(XPG homolog) (ERCC5 homolog) (RAD2 homolog) (AtUVH3) (AtXPG)(AtRAD2).
Molecular weight: 1656
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
07-MAR-2006, entry version 23.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVH3_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF312711 | AAK37472.1 | - |
| EMBL | AB028616 | BAB01125.1 | ALT_SEQ |
| GenomeReviews | BA000014_GR | AT3G28030.1 | |
| GeneFarm | 4444 | -.1 | |
| TAIR | At3g28030 | -.1 | |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR006086 | XPG_I. | |
| InterPro | IPR006085 | XPG_N. | |
| InterPro | IPR001044 | XPGC_DNA_repair. | |
| InterPro | IPR006084 | XPGC_Rad. | |
| Pfam | PF00867 | XPG_I | 1. |
| Pfam | PF00752 | XPG_N | 1. |
| PRINTS | PR00853 | XPGRADSUPER. | |
| PRINTS | PR00066 | XRODRMPGMNTG. | |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00484 | XPGI | 1. |
| SMART | SM00485 | XPGN | 1. |
| PROSITE | PS00841 | XPG_1 | 1. |
| PROSITE | PS00842 | XPG_2 | 1. |
Keywords:
DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclear protein; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE, FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX MEDLINE=21332854; PubMed=11439121;
RA Liu Z., Hall J.D., Mount D.W.;
RT "Arabidopsis UVH3 gene is a homolog of the Saccharomyces cerevisiae
RT RAD2 and human XPG DNA repair genes.";
RL Plant J. 26:329-338(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=20363099; PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II.
RT Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC
RT and BAC clones.";
RL DNA Res. 7:217-221(2000).
Feature:
CHAIN 1 1479 DNA-repair protein UVH3.
/FTId=PRO_0000154034.
REGION 1 98 N-domain.
REGION 934 1022 I-domain.
Comments:
-!- FUNCTION: Putative single-stranded DNA endonuclease involved in
nucleotide excision repair (NER) of UV- and oxidative damaged DNA.
May make the 3'-incision step in NER. Seems to play a role in
senescence program.
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- TISSUE SPECIFICITY: Expressed in all tissues at low levels.
-!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. XPG
subfamily.
-!- CAUTION: Ref.2 sequence differs from that shown due to erroneous
gene model prediction.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 1479
MGVQGLWELL APVGRRVSVE TLANKRLAID ASIWMVQFIK AMRDEKGDMV QNAHLIGFFR
RICKLLFLRT KPIFVFDGAT PALKRRTVIA RRRQRENAQT KIRKTAEKLL LNRLKDIRLK
EQAKDIKNQR LKQDDSDRVK KRVSSDSVED NLRVPVEEDD VGASFFQEEK LDEVSQASLV
GETGVDDVVK ESVKDDPKGK GVLLDGDDLD NLVQDSSVQG KDYQEKLDEM LAASLAAEEE
RNFTSKASTS AAAIPSEEDE EEDSDGDEEI LLPVMDGNID PAVLASLPPS MQLDLLAQMR
EKLMAENRQK YQKVKKAPEK FSELQIEAYL KTVAFRREIN EVQRSAGGRA VGGVQTSRIA
SEANREFIFS SSFAGDKEVL ASAREGRNDE NQKKTSQQSL PVSVKNASPL KKSDATIELD
RDEPKNPDEN IEVYIDERGR FRIRNRHMGI QMTRDIQRNL HLMKEKERTA SGSMAKNDET
FSAWENFPTE DQFLEKSPVE KDVVDLEIQN DDSMLHPPSS IEISFDHDGG GKDLNDEDDM
FLQLAAGGPV TISSTENDPK EDTSPWASDS DWEEVPVEQN TSVSKLEANL SNQHIPKDIS
IAEGVAWEEY SCKNANNSVE NDTVTKITKG YLEEEADLQE AIKKSLLELH DKESGDVLEE
NQSVRVNLVV DKPSEDSLCS RETVGEAEEE RFLDEITILK TSGAISEQSN TSVAGNADGQ
KGITKQFGTH PSSGSNNVSH AVSNKLSKVK SVISPEKALN VASQNRMLST MAKQHNEEGS
ESFGGESVKV SAMPIADEEI TGFLDEKDNA DGESSIMMDD KRDYSRRKIQ SLVTESRDPS
RNVVRSRIGI LHDTDSQNER REENNSNEHT FNIDSSTDFE EKGVPVEFSE ANIEEEIRVL
DQEFVSLGDE QRKLERNAES VSSEMFAECQ ELLQIFGIPY IIAPMEAEAQ CAFMEQSNLV
DGIVTDDSDV FLFGARSVYK NIFDDRKYVE TYFMKDIEKE LGLSRDKIIR MAMLLGSDYT
EGISGIGIVN AIEVVTAFPE EDGLQKFREW VESPDPTILG KTDAKTGSKV KKRGSASVDN
KGIISGASTD DTEEIKQIFM DQHRKVSKNW HIPLTFPSEA VISAYLNPQV DLSTEKFSWG
KPDLSVLRKL CWEKFNWNGK KTDELLLPVL KEYEKRETQL RIEAFYSFNE RFAKIRSKRI
NKAVKGIGGG LSSDVADHTL QEGPRKRNKK KVAPHETEDN NTSDKDSPIA NEKVKNKRKR
LEKPSSSRGR GRAQKRGRGR GRVQKDLLEL SDGSSDDDDD DDKVVELEAK PANLQKSTRS
RNPVMYSAKE DDELDESRSN EGSPSENFEE VDEGRIGNDD SVDASINDCP SEDYIQTGGG
FCADEADEIG DAHLEDKATD DYRVIGGGFC VDEDETAEEN TMDDDAEILK MESEEQRKKG
KRRNEEDASL DENVDIHFGN SSAGGLSAMP FLKRKKRKN