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Description:
DNA repair helicase XPB2 (EC 3.6.1.-) (XPB homolog 2) (ERCC3 homolog2) (RAD25 homolog 2) (AtXPB2).
Molecular weight: 86736
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
07-MAR-2006, entry version 27.
Phylogenetic order:
Eukaryota Viridiplantae Streptophyta Embryophyta Tracheophyta Spermatophyta Magnoliophyta eudicotyledons core eudicotyledons rosids eurosids II Brassicales Brassicaceae Arabidopsis.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein XPB2_ARATH:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF308595 | AAG27465.1 | - |
| EMBL | AY550923 | AAT36214.1 | - |
| EMBL | AB006707 | BAB08508.1 | ALT_SEQ |
| PIR | S71206 | S71206. | |
| GenomeReviews | BA000015_GR | AT5G41360.1 | |
| GeneFarm | 4454 | 455.1 | |
| TAIR | At5g41360 | -.1 | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR001650 | Helicase_C. | |
| InterPro | IPR001161 | XPB_DNA_repair. | |
| PANTHER | PTHR11274 | XPB_DNA_repair.1 | 1. |
| Pfam | PF00270 | DEAD | 1. |
| Pfam | PF00271 | Helicase_C | 1. |
| PRINTS | PR00851 | XRODRMPGMNTB. | |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00490 | HELICc | 1. |
| TIGRFAMs | TIGR00603 | rad25 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nuclear protein; Nucleotide-binding; Transcription; Transcription regulation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=21605276; PubMed=11737776;
RA Costa R.M.A., Morgante P.G., Berra C.M., Nakabashi M., Bruneau D.,
RA Bouchez D., Sweder K.S., Van Sluys M.-A., Menck C.F.M.;
RT "The participation of AtXPB1, the XPB/RAD25 homologue gene from
RT Arabidopsis thaliana, in DNA repair and plant development.";
RL Plant J. 28:385-395(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Landsberg erecta;
RA Morgante P.G., Berra C.M., Nakabashi M., Costa R.M.A., Menck C.F.M.,
RA Van Sluys M.-A.;
RT "Functional XPB/RAD25 redundancy in Arabidopsis genome:
RT characterization of AtXPB2 and expression analysis.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX MEDLINE=98069011; PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II.
RT Sequence features of the regions of 1,044,062 bp covered by thirteen
RT physically assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
Feature:
CHAIN 1 766 DNA repair helicase XPB2.
/FTId=PRO_0000101992.
NP_BIND 306 313 ATP (By similarity).
MOTIF 408 411 DEVH box.
MOTIF 749 765 Nuclear localization signal (Potential).
Comments:
-!- FUNCTION: Putative ATP-dependent 3'-5' DNA helicase involved in
nucleotide excision repair (NER) of DNA. May be involved in RNA
transcription by RNA polymerase II. Acts by opening DNA around
either the RNA transcription start site or the DNA damage (By
similarity).
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
-!- CAUTION: Ref.3 sequence differs from that shown due to erroneous
gene model prediction.
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Sequence length: 766
MGNDERKRPT KKMKYGGKDD QKMKNIQNVE DYYDDADEDS RDGEGEEKRR DFTDLELKPD
HGNRPLWACA DGKIFLETFS PLYKQAYDFL IAIAEPVCRP ESMHEYNLTP HSLYAAVSVG
LETETIISVL NKLSKTKLPG EIIDFIHAST ANYGKVKLVL KKNRYFIESP FPEVLKRLLS
DDVINRARFT SEPYYGGDGF TIGKTSGELE AGPGELLNEA ELAAAAEEKE THSFEIDPAL
VENVKQRCLP NALNYPMLEE YDFRNDNVNP DLDMELKPHA QPRPYQEKSL SKMFGNGRAR
SGIIVLPCGA GKSLVGVSAA ARIKKSCLCL ATNAVSVDQW AYQFKLWSTI KDDQICRFTS
DSKERFRGNA GVVVTTYNMI AFGGKRSEEA EKIIEEMRNR EWGLLLMDEV HVVPAHMFRK
VISITKSHCK LGLTATLVRE DEKITDLNFL IGPKLYEANW LDLVKGGFIA NVQCAEVWCP
MTKEFFAEYL KKENSKKKQA LYVMNPNKFR ACEFLIRFHE QQRGDKIIVF ADNLFALTEY
AMKLRKPMIY GATSHIERTK ILEAFKTSKT VNTVFLSKVG DNSIDIPEAN VIIQISSHAG
SRRQEAQRLG RILRAKGKLE DRMAGGKEEY NAFFYSLVST DTQEMYYSTK RQQFLIDQGY
SFKVITSLPP PDAGSSLGYH SQEEQLSLLG KVLNAGDDMV GLEQLEEDTD GKALKTRRSM
GSMSAMSGAN GRVYMEYNSG RQKSGNQSKK PKDPTKRHNI FKKRYV