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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10954
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Bradyrhizobiaceae Bradyrhizobium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_BRAJA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000040 | BAC49967.1 | - |
| GenomeReviews | BA000040_GR | blr4702.1 | |
| BioCyc | BJAP224911:BLR4702-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 2. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=USDA 110;
RX MEDLINE=22484998; PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T.,
RA Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K.,
RA Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M.,
RA Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
Feature:
CHAIN 1 991 UvrABC system protein A.
/FTId=PRO_0000093037.
DOMAIN 400 630 ABC transporter 1.
DOMAIN 644 972 ABC transporter 2.
NP_BIND 48 55 ATP (Potential).
NP_BIND 676 683 ATP (Potential).
ZN_FING 775 801 C4-type.
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 991
MDEVIKAKRQ QQNAGSSLRA ITIRGAREHN LKNIDVEIPR DKLVVFTGLS GSGKSSLAFD
TIYAEGQRRY VESLSAYARQ FLEMMQKPDV DQIDGLSPAI SIEQKTTSKN PRSTVGTVTE
IYDYMRLLWA RVGVPYSPAT GLPIESQTVS QMVDRVLALP EGTRLYLLAP VVRGRKGEYR
KELAEWLKKG FQRVKIDGTF HELAEAPTLD KKFPHDIDVV VDRIVVRADI GQRLAESFET
ALKLAEGLAV VEFADAPAAA PAEEKKKTAK IHDKSGPERI LFSEKFACPV SGFTIPEIEP
RLFSFNNPYG ACPACGGLGV EQHVDEDLVI PDKELAIGKG AIAPWAKSSS PYYVQTLTAL
GKHYKFTLTT KWKDLPKKTR DAILHGSGED EIKFSYEDGV RSYDTKKPFE GVITNINRRY
RETESEWARE ELAKYFHDVP CGACNGFRLK PEALCVKVGT KHIGEISELS VKKAGEWFET
VPEALNKQQN EIAGRILKEI RERLTFLLDV GLNYLTLSRS SGTLSGGESQ RIRLASQIGS
GLTGVLYVLD EPSIGLHQRD NARLLDTLKR LRDLGNTVVV VEHDEDAIRL ADYVLDIGPG
AGMHGGHIVA EGTPAEIMRN PKSLTGKYLT GELEVEVPER RPPNHRRTIK VVNARGNNLK
NVTAEIPLGL FTCVTGVSGG GKSTLLIDTL YRAIARKLNN ASEGAAPHDR IEGLEHIDKI
IDIDQSPIGR TPRSNPATYT GAFTPIREWF AGLPEAKARG YEPGRFSFNV KGGRCEACQG
DGVIKIEMHF LPDVYVTCDV CKGKRYNRET LEVLFKGKSI ADVLDMTVEE AADFFKAVPR
VRETFQTLHR VGLDYIHVGQ QATTLSGGEA QRVKLAKELS KRATGRTLYI LDEPTTGLHF
HDVKKLLEVL HELVAQGNTV VVIEHNLEVI KTADWVIDLG PEGGDGGGEI VAWGPPEDIA
KAPRSYTGKF LEPVLKKARK PKRRSTSEAA E