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Description:
DNA mismatch repair protein mutL.
Molecular weight: 65105
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 22.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Sinorhizobium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTL_RHIME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL591785 | CAC45388.1 | - |
| HSSP | P23367 | 1BKN | |
| GenomeReviews | AL591688_GR | R00816.1 | |
| BioCyc | SMEL382:SMC00932-MONOMER | -.1 | |
| HAMAP | MF_00149 | - | 1. |
| InterPro | IPR003594 | ATP_bd_ATPase. | |
| InterPro | IPR002099 | DNA_mis_repair. | |
| PANTHER | PTHR10073 | DNA_mis_repair.1 | 1. |
| Pfam | PF01119 | DNA_mis_repair | 1. |
| Pfam | PF02518 | HATPase_c | 1. |
| TIGRFAMs | TIGR00585 | mutl | 1. |
| PROSITE | PS00058 | DNA_MISMATCH_REPAIR_1 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont
RT Sinorhizobium meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
Feature:
CHAIN 1 605 DNA mismatch repair protein mutL.
/FTId=PRO_0000177963.
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is required for dam-dependent methyl-directed DNA mismatch
repair. May act as a "molecular matchmaker", a protein that
promotes the formation of a stable complex between two or more
DNA-binding proteins in an ATP-dependent manner without itself
being part of a final effector complex (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutL/hexB family.
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Sequence length: 605
MAIKQLSETL INQIAAGEVI ERPASAAKEL IENALDAGAT RIEIATAGGG KTLLRVTDNG
IGMSPADLEL AIRRHCTSKL NDSLADIRTL GFRGEALPSI GSVARLSITT RTAEAREGAA
ITVTGGRSEP ARPSAAIVGT VVEVRDLFFA TPARLKFMKS EKAEAAAISE VVRRMAIAFP
RVRFVLSGSD RTTLEFPATG DDRLARMAQV LGRDFRDNAI EIDAEREGAR LTGFAGVPTF
NRGNSLQQYA FVNGRPVQDK LIMSALRAAY AETIPQGRYP IAVLSITLDP ALVDVNVHPA
KSDVRFRDPG LIRGLIIGAI REALTREGDR AATTGAHGLM RAFRPEFHRA GQQRPQEPWS
AAASPHRPLR FEEAARGFAE APQAAFSDFA QPSARSAAAA VEATRATDGQ AASFPLGAAR
AQLHENYIVA QTDDGLVIVD QHAAHERLVF ETMRTALHAR PVPAQALLIP EIVGLPEDDC
DRLMAHAEEF TRLGLAIERF GPAAVAVRET PAMLGEMDAA GLVRQLADEL AEWDTASGLA
GRLEYLAATM ACHGSVRSGR RLRTEEMNAL LRQMEATPGS GQCNHGRPTY IELKLADIER
LFGRS