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Description:
Holliday junction ATP-dependent DNA helicase ruvB (EC 3.6.1.-).
Molecular weight: 38181
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
03-APR-2002, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-MAR-2006, entry version 32.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Sinorhizobium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVB_RHIME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL591791 | CAC47328.1 | - |
| HSSP | Q56313 | 1IN4 | |
| GenomeReviews | AL591688_GR | R02749.1 | |
| BioCyc | SMEL382:SMC03965-MONOMER | -.1 | |
| HAMAP | MF_00016 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003959 | AAA_ATPase_centr. | |
| InterPro | IPR000641 | CbxX_CfqX. | |
| InterPro | IPR004605 | RuvB. | |
| InterPro | IPR008823 | RuvB_C. | |
| InterPro | IPR008824 | RuvB_N. | |
| InterPro | IPR011991 | Wing_hlx_DNA_bd. | |
| Pfam | PF00004 | AAA | 1. |
| Pfam | PF05491 | RuvB_C | 1. |
| Pfam | PF05496 | RuvB_N | 1. |
| PRINTS | PR00819 | CBXCFQXSUPER. | |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR00635 | ruvB | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; Helicase; Hydrolase; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont
RT Sinorhizobium meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
Feature:
CHAIN 1 346 Holliday junction ATP-dependent DNA
helicase ruvB.
/FTId=PRO_0000165584.
NP_BIND 60 67 ATP (Potential).
Comments:
-!- FUNCTION: The ruvA-ruvB complex in the presence of ATP renatures
cruciform structure in supercoiled DNA with palindromic sequence,
indicating that it may promote strand exchange reactions in
homologous recombination. RuvAB is an helicase that mediates the
Holliday junction migration by localized denaturation and
reannealing (By similarity).
-!- SUBUNIT: Forms a complex with ruvA (By similarity).
-!- SIMILARITY: Belongs to the ruvB family.
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Sequence length: 346
MSEAARLIAP EKRGEDLDAT MRPQTLDEFT GQAEARANLK IFIEAARNRG EALDHVLFVG
PPGLGKTTLA QIMAKELGVN FRSTSGPVIA KAGDLAALLT NLEERDVLFI DEIHRLNPAV
EEILYPAMED FQLDLIIGEG PAARSVKIDL AKFTLVAATT RLGLLTTPLR DRFGIPVRLN
FYTVEELELI VRRGARLMGL GMTDEGAREI ARRARGTPRI AGRLLRRVRD FAEVARAEAV
TLKIADEALT RLLVDSMGLD QLDRRYLTMI AQNFGGGPVG IETIAAGLSE PRDAIEDIIE
PYLIQQGFIQ RTPRGRVLTA NAWKHLGLNP PRDVEASQFR LTLEDD