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Description:
UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A).
Molecular weight: 10719
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
30-MAY-2000, sequence version 1.
07-MAR-2006, entry version 41.
Phylogenetic order:
Bacteria Proteobacteria Alphaproteobacteria Rhizobiales Rhizobiaceae Sinorhizobium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVRA_RHIME:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL591787 | CAC46136.1 | - |
| EMBL | AF125162 | AAF03210.1 | - |
| HSSP | P58301 | 1F2U | |
| GenomeReviews | AL591688_GR | R01557.1 | |
| BioCyc | SMEL382:SMC01235-MONOMER | -.1 | |
| HAMAP | MF_00205 | - | 1. |
| InterPro | IPR003439 | ABC_transp_like. | |
| InterPro | IPR004602 | UvrA_ABC. | |
| Pfam | PF00005 | ABC_tran | 1. |
| ProDom | PD000006 | ABC_transporter | 1. |
| TIGRFAMs | TIGR00630 | uvra | 1. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | 2. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA excision; DNA repair; DNA-binding; Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX MEDLINE=21396507; PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont
RT Sinorhizobium meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140.
RC STRAIN=2021;
RX MEDLINE=99430868; PubMed=10503543; DOI=10.1007/s004380051066;
RA Tapias A., Barbe J.;
RT "Regulation of divergent transcription from the uvrA-ssb promoters in
RT Sinorhizobium meliloti.";
RL Mol. Gen. Genet. 262:121-130(1999).
Feature:
CHAIN 1 973 UvrABC system protein A.
/FTId=PRO_0000093082.
DOMAIN 286 615 ABC transporter 1.
DOMAIN 630 958 ABC transporter 2.
NP_BIND 34 41 ATP (Potential).
NP_BIND 662 669 ATP (Potential).
ZN_FING 761 787 C4-type.
CONFLICT 19 19 G -> A (in Ref. 2).
CONFLICT 67 67 F -> S (in Ref. 2).
Comments:
-!- FUNCTION: The UvrABC repair system catalyzes the recognition and
processing of DNA lesions. UvrA is an ATPase and a DNA-binding
protein. A damage recognition complex composed of 2 uvrA and 2
uvrB subunits scans DNA for abnormalities. When the presence of a
lesion has been verified by uvrB, the uvrA molecules dissociate
(By similarity).
-!- SUBUNIT: Forms a heterotetramer with uvrB during the search for
lesions (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family. UvrA subfamily.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 973
MSELKTISIR GAREHNLKGI DLDLPRNKLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL
SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST VGTVTEIYDY LRLLFARVGV
PYSPATGLPI ESQTVSQMVD RVLEFGEGTR LYMLAPLVRG RKGEYRKELA ELMKKGFQRV
KVDGQFYEIA DVPALDKKYK HDIDVVVDRV VVRPDIGTRL ADSIETCLTL ADGLAIAEFA
DRPLPPEETS AGGSANKSLN ETHERVLFSE KFACPVSGFT IPEIEPRLFS FNNPFGACTT
CDGLGSQQKI DEALIVPEPN RTLRDGAIAP WAKSTSPYYN QTLEALGTVF GFKLGSRWSE
LSEEAQEAIL HGTKDKITFH YQDGARSYNT TKTFEGIVPN LERRWKETDS AWAREEIERY
MSAAPCPACA GYRLKPEALA VKIHALHIGE VSEMSIRAAR DWFEVLPEHL STKQNEIAVR
ILKEIRERLR FLNDVGLEYL SLSRNSGTLS GGESQRIRLA SQIGSGLTGV LYVLDEPSIG
LHQRDNARLL DTLRHLRDIG NTVIVVEHDE DAILTADYVV DIGPAAGIHG GEVIAEGTPS
DIMSNPKSLT GKYLSGELSV AVPGERRKPK KKKEVTVVGA RANNLKNVTA SIPLGVFTAV
TGVSGGGKST FLIETLYKAA ARRVMGAREN PAEHDRIDGF EHIDKVIDID QSPIGRTPRS
NPATYTGAFT PIRDWFAGLP EAKARGYQPG RFSFNVKGGR CEACQGDGVI KIEMHFLPDV
YVTCDVCHGK RYNRETLDVH FKGKSIADVL DMTVEEGVEF FAAVPAVRDK LVTLNQVGLG
YIKIGQQANT LSGGEAQRVK LAKELSKRST GRTLYILDEP TTGLHFHDVA KLLEVLHELV
NQGNSVVVIE HNLEVIKTAD WIIDFGPEGG DGGGEVIAQG TPEEVVKEPR SYTGQFLKEL
LERRPVKKVV AAE