Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG) (Fragment).
Molecular weight: 29517
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-FEB-2006, entry version 32.
Phylogenetic order:
Eukaryota Mycetozoa Dictyosteliida Dictyostelium.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_DICDI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U32866 | AAA75334.1 | - |
| HSSP | P13051 | 1AKZ | |
| DictyBase | DDB0001922 | uglA.1 | |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Guyer R.B., Deering R.A.;
RL Submitted (SEP-1995) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN <1 257 Uracil-DNA glycosylase.
/FTId=PRO_0000176172.
COMPBIAS 1 5 Poly-Asn.
ACT_SITE 97 97 Proton acceptor (By similarity).
NON_TER 1 1
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine.
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 257
NNNNNKKLKN EEKSEEINST ITDNNYYDDI ENYFTDKQWK EALSGEFGKA YFKKMITQLN
KRYSSKEKPI YPPKNEIFSA FNYAHLEDVK VVIIGQDPYH GKGQAHGLSF SVKKGVSPPP
SLINIYKELE TDIEGFKRPL KNGFLEPWAR QGVFLLNAVL TVEEATPNSH KDFGWADFTD
AVLKILSKQD QPIVFILWGG FAQKKEKLFT NKNHLVLKSG HPSPLSIKHF IGCKHFSKSN
EFLKSKGIEE IDWKITE