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Description:
Actin-like protein arp4.
Molecular weight: 48773
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 25.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein ARP4_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL136535 | CAB66436.1 | - |
| PIR | T50395 | T50395. | |
| HSSP | P02577 | 1NM1 | |
| GeneDB_Spombe | SPBP23A10.08 | -.1 | |
| GO | GO:0043189 | C:H4/H2A histone acetyltransferase complex | IDA. |
| GO | GO:0005634 | C:nucleus | IDA. |
| GO | GO:0008608 | P:attachment of spindle microtubules to kinet... | IMP. |
| GO | GO:0030702 | P:chromatin silencing at centromere | IMP. |
| GO | GO:0000070 | P:mitotic sister chromatid segregation | IMP. |
| GO | GO:0035065 | P:regulation of histone acetylation | IGI. |
| GO | GO:0007346 | P:regulation of progression through mitotic c... | IMP. |
| InterPro | IPR004001 | Actin. | |
| InterPro | IPR004000 | Actin_like. | |
| PANTHER | PTHR11937 | Actin_like.1 | 3. |
| Pfam | PF00022 | Actin | 1. |
| PRINTS | PR00190 | ACTIN. | |
| SMART | SM00268 | ACTIN | 1. |
| PROSITE | PS00406 | ACTINS_1 | FALSE_NEG. |
| PROSITE | PS00432 | ACTINS_2 | 1. |
| PROSITE | PS01132 | ACTINS_ACT_LIKE | FALSE_NEG. |
Keywords:
Activator; Chromatin regulator; Complete proteome; DNA damage; DNA repair; Nuclear protein; Transcription; Transcription regulation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 433 Actin-like protein arp4.
/FTId=PRO_0000089100.
Comments:
-!- FUNCTION: Chromatin interaction component of the NuA4 histone
acetyltransferase complex which is involved in transcriptional
activation of selected genes principally by acetylation of
nucleosomal histone H4 and H2A. The NuA4 complex is also involved
in DNA repair. Is required for NuA4 complex integrity. Component
of the SWR1 complex which mediates the ATP-dependent exchange of
histone H2A for the H2A variant HZT1 leading to transcriptional
regulation of selected genes by chromatin remodeling. Component of
the INO80 complex which remodels chromatin by shifting nucleosomes
and is involved in DNA repair (By similarity).
-!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex,
of the INO80 chromatin remodeling complex, and of the SWR1
chromatin remodeling complex (By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (By similarity).
-!- SIMILARITY: Belongs to the actin family. ARP4 subfamily.
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Sequence length: 433
MTSAFYGGDE VSAIVIDPGS KWTRIGFSGE DIPKCVLPSY CGEFSDGRRL FGEEYIYKSN
PGMEIKNAIR NGWVENWDVT VDLWRYGLEQ QLKTNPLEHP ILITEPFDNP PENRVKTLET
MFESLRCPAT YLAKQETCAA FASGKGTACL VDIGAERSSV SAIYDGFVLQ KGYQVQHFSG
NAINDILAQT LRDKNFEVMP KYLVKSKNPV EIGQPANCEL RPRDTTDSYH QFQVQRVYDE
WKEECALISD VPFSSETTIA ESEFEFPDGS RMMFGAERYQ IPEHLFVPGS DEEMNEEPSK
PIEQTENNEV SQQDSSVTNT SSRILGIPQL FQNCISECDV DIRASLLNNV IVCGGTSLMQ
GFSLRLQNEL SKLYPGSRLK IHASGHVVER SYASWLGGSI LSSLGTFHQL WISRQEYEEH
GSDRLALIEK RCK