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Description:
Mismatch-binding protein cmb1.
Molecular weight: 26304
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-FEB-2006, entry version 37.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein CMB1_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ002513 | CAA05504.1 | - |
| EMBL | Z69727 | CAA93561.1 | - |
| PIR | T38870 | T38870. | |
| GeneDB_Spombe | SPAC4G9.11c | -.1 | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-001359-MONOMER | -.1 | |
| GO | GO:0003684 | F:damaged DNA binding | IDA. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| InterPro | IPR000910 | HMG_12_box. | |
| Pfam | PF00505 | HMG_box | 1. |
| SMART | SM00398 | HMG | 1. |
| PROSITE | PS50118 | HMG_BOX_2 | 1. |
Keywords:
Complete proteome; DNA-binding; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC STRAIN=972;
RX MEDLINE=99023965; PubMed=9804804; DOI=10.1074/jbc.273.46.30398;
RA Fleck O., Kunz C., Rudolph C., Kohli J.;
RT "The high mobility group domain protein cmb1 of Schizosaccharomyces
RT pombe binds to cytosines in base mismatches and opposite chemically
RT altered guanines.";
RL J. Biol. Chem. 273:30398-30405(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 223 Mismatch-binding protein cmb1.
/FTId=PRO_0000048805.
DNA_BIND 147 221 HMG box.
Comments:
-!- FUNCTION: Binds to cytosines in base mismatches and opposite
chemically altered guanines.
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- SIMILARITY: Contains 1 HMG box DNA-binding domain.
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Sequence length: 223
MRLFDAMPPY LTYQAPLSLI IFHKMVFAIR IRQFHTTLVS AEKNGLQKLI PPRLKTIWNQ
MLVETKGAGN GPERFEMIRQ KYKALTADEI QKYKNKLQEQ FDAEKKRFME TLRSFTPTEI
DSENRRRSKE AHSTGSRYYR LRHPDVPKKP SSAFILFYKE LRNNPKLRQE LGIPEAISTL
VEETQNASKA WKELAEDKKK PFIDKSKALK EQYDKFMKEA GFR