Protein data for DDB1_SCHPO:

Description:
DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1).

Molecular weight: 1206

View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )

Important dates:
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-FEB-2006, entry version 26.

Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.

To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html

Links to references in other databases for protein DDB1_SCHPO:

Database Pointer Add. info#1 Add. info#2
EMBL Z98597 CAB11219.1 -
PIR T37876 T37876.
GeneDB_Spombe SPAC17H9.10c -.1
BioCyc SPOM-XXX-01:SPOM-XXX-01-001254-MONOMER -.1
GO GO:0005730 C:nucleolus IDA.
GO GO:0007059 P:chromosome segregation IMP.
GO GO:0000076 P:DNA replication checkpoint IGI.
GO GO:0051321 P:meiotic cell cycle IGI.
GO GO:0019941 P:modification-dependent protein catabolism IGI.
GO GO:0006997 P:nuclear organization and biogenesis IMP.
GO GO:0006279 P:premeiotic DNA synthesis TAS.
GO GO:0007090 P:regulation of S phase of mitotic cell cycle IMP.
GO GO:0006974 P:response to DNA damage stimulus IMP.
GO GO:0009411 P:response to UV IMP.
InterPro IPR004871 CPSF_A_C.
Pfam PF03178 CPSF_A 1.

General information about the databases mentioned above

Keywords:
Complete proteome; DNA damage; DNA repair; DNA-binding; Nuclear protein.

References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=12857752; DOI=10.1074/jbc.M303003200;
RA Bondar T., Mirkin E.V., Ucker D.S., Walden W.E., Mirkin S.M.,
RA Raychaudhuri P.;
RT "Schizosaccharomyces pombe Ddb1 is functionally linked to the
RT replication checkpoint pathway.";
RL J. Biol. Chem. 278:37006-37014(2003).

Feature:
CHAIN 1 1072 DNA damage-binding protein 1.
/FTId=PRO_0000079843.

Comments:
-!- FUNCTION: Involved in the stabilization of replication forks. Has
an indirect role in controlling the activation of protein kinase
cds1.
-!- SUBCELLULAR LOCATION: Nucleus (By similarity).
-!- SIMILARITY: Belongs to the DDB1 family.
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Sequence length: 1072

     MTYVTYLHKP SSIRNAVFCK FVNASSWNVI VAKVNCLEVY SYENNRLCLI TSANIFAKIV
     NVKAFKPVSS PTDHIIVATD SFRYFTLFWD ANDNTVSNGI KIQDCSERSL RESQSGPLLL
     VDPFQRVICL HVYQGLLTII PIFKSKKRFM TSHNNPSLHD NFSVRIQELN VVDIAMLYNS
     SRPSLAVLYK DSKSIVHLST YKINVREQEI DEDDVVCHDI EEGKLIPSEN GGVFVFGEMY
     VYYISKDIQV SKLLLTYPIT AFSPSISNDP ETGLDSSIYI VADESGMLYK FKALFTDETV
     SMELEKLGES SIASCLIALP DNHLFVGSHF NNSVLLQLPS ITKNNHKLEI LQNFVNIAPI
     SDFIIDDDQT GSSIITCSGA YKDGTLRIIR NSINIENVAL IEMEGIKDFF SVSFRANYDN
     YIFLSLICET RAIIVSPEGV FSANHDLSCE ESTIFVSTIY GNSQILQITT KEIRLFDGKK
     LHSWISPMSI TCGSSFADNV CVAVAGGLIL FFEGITEVGR YQCDTEVSSL CFTEENVVYV
     GLWSADIIML TYCQDGISLT HSLKLTDIPR SIVYSQKYGD DGGTLYVSTN NGYVLMFNFQ
     NGQVIEHSLR RNQLGVAPII LKHFDSKEKN AIFALGEKPQ LMYYESDKLV ITPLSCTEML
     NISSYVNPSL GVNMLYCTNS YISLAKMSEI RSLNVQTVSV KGFPRRICSN SLFYFVLCMQ
     LEESIGTQEQ RLLSFLRVYE KNTLSEIAHH KFNEYEMVES IILMNDDKRV VVGTGFNFPD
     QDAPDSGRLM VFEMTSDNNI EMQAEHKVQG SVNTLVLYKH LIVAGINASV CIFEYEHGTM
     HVRNSIRTPT YTIDISVNQD EIIAADLMKS ITVLQFIDDQ LIEVARDYHP LWATSVEILS
     ERKYFVTEAD GNAVILLRDN VSPQLSDRKK LRWYKKFYLG ELINKTRHCT FIEPQDKSLV
     TPQLLCATVD GSLMIVGDAG MSNTPLLLQL QDNIRKVIPS FGGLSHKEWK EYRGENETSP
     SDLIDGSLIE SILGLREPIL NEIVNGGHEG TKLDISVQDL KSIIENLEKL HP

Back

Database	Pointer	Add. info#1	Add. info#2
EMBL	Z98597	CAB11219.1	-
PIR	T37876	T37876.
GeneDB_Spombe	SPAC17H9.10c	-.1
BioCyc	SPOM-XXX-01:SPOM-XXX-01-001254-MONOMER	-.1
GO	GO:0005730	C:nucleolus	IDA.
GO	GO:0007059	P:chromosome segregation	IMP.
GO	GO:0000076	P:DNA replication checkpoint	IGI.
GO	GO:0051321	P:meiotic cell cycle	IGI.
GO	GO:0019941	P:modification-dependent protein catabolism	IGI.
GO	GO:0006997	P:nuclear organization and biogenesis	IMP.
GO	GO:0006279	P:premeiotic DNA synthesis	TAS.
GO	GO:0007090	P:regulation of S phase of mitotic cell cycle	IMP.
GO	GO:0006974	P:response to DNA damage stimulus	IMP.
GO	GO:0009411	P:response to UV	IMP.
InterPro	IPR004871	CPSF_A_C.
Pfam	PF03178	CPSF_A	1.