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Description:
Enhancer of polycomb-like protein 1.
Molecular weight: 64628
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
07-FEB-2006, entry version 21.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EPL1_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL109850 | CAB52878.1 | - |
| PIR | T41631 | T41631. | |
| GeneDB_Spombe | SPCC830.05c | -.1 |
Keywords:
Cell cycle; Complete proteome; DNA damage; DNA repair; Nuclear protein; Transcription; Transcription regulation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 557 Enhancer of polycomb-like protein 1.
/FTId=PRO_0000214165.
COMPBIAS 235 260 Arg-rich.
COMPBIAS 316 349 Pro-rich.
Comments:
-!- FUNCTION: Component of the NuA4 histone acetyltransferase complex
which is involved in transcriptional activation of selected genes
principally by acetylation of nucleosomal histone H4 and H2A. The
NuA4 complex is also involved in DNA repair. Involved in gene
silencing by neighboring heterochromatin, blockage of the
silencing spreading along the chromosome, and required for cell
cycle progression through G2/M (By similarity).
-!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex
(By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (By similarity).
-!- SIMILARITY: Belongs to the enhancer of polycomb family.
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Sequence length: 557
MSSVSKNARA YRQRKVGIKT VMPIYFERDI PDFDEEASLQ RTVPLVESGV EKEEEEEKHL
QQVINEAHEA IVRGSEKKLI IPTREAKNIG IIDKYYKKNF ILPKTLIRFS LTVEECTNPE
YCMDEHDTEY FLKLKQAQPS LSKFSELDFE IVMQTFEEEI NQNQPFLSMD TSQILPLSEL
ITSFELKDVL YLKPLASQVY PYWRERRISK GGLPIMAKAQ VGDDKDDDDP YVCFRRREIR
QARKTRRSDA QSYDRLRRLR QSMETSLQLL EQVYKREQKK LQALEDDYAI FQKRCLVKKL
KRTLNIKDSD ELLINPKRRP IEVKPAAPVP TPAPPVKTSP HPASYRPQPT RNVEVRPLLM
LDDVQSAQIT QFQIRLQQRL TKKEQLDRNW VDLLETPSTV IHTNYPDSFY RNIIPYYSGK
ETKQSHNQLS IPSSTPSTPL SDNGPTYSTP HSSLSNFNTC DSLSFSSNNS LYGYSTLLHP
RNPICVRQRI GRGGRLMLDR TRALPVHRLS KPKSRVEDRW LFDIPFDADD TIILDDESDA
SIMFRASLLN DDMGTQS