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Description:
Exodeoxyribonuclease 1 (EC 3.1.-.-) (Exodeoxyribonuclease I)(Exonuclease I) (EXO I).
Molecular weight: 63867
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 ) mismatch repair( GO:0006298 )
Important dates:
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
07-FEB-2006, entry version 41.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EXO1_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L35174 | AAC41648.1 | - |
| EMBL | AL034463 | CAA22433.1 | - |
| PIR | T43288 | T43288. | |
| GeneDB_Spombe | SPBC29A10.05 | -.1 | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-004097-MONOMER | -.1 | |
| GO | GO:0008409 | F:5'-3' exonuclease activity | IMP. |
| GO | GO:0000706 | P:meiotic DNA double-strand break processing | TAS. |
| GO | GO:0006298 | P:mismatch repair | IMP. |
| GO | GO:0006312 | P:mitotic recombination | TAS. |
| GO | GO:0000723 | P:telomere maintenance | TAS. |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR006086 | XPG_I. | |
| InterPro | IPR006085 | XPG_N. | |
| InterPro | IPR006084 | XPGC_Rad. | |
| Pfam | PF00867 | XPG_I | 1. |
| Pfam | PF00752 | XPG_N | 1. |
| PRINTS | PR00853 | XPGRADSUPER. | |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00484 | XPGI | 1. |
| SMART | SM00485 | XPGN | 1. |
| PROSITE | PS00841 | XPG_1 | 1. |
| PROSITE | PS00842 | XPG_2 | 1. |
Keywords:
Complete proteome; Direct protein sequencing; DNA damage; DNA repair; DNA-binding; Excision nuclease; Exonuclease; Hydrolase; Nuclear protein; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 139-160.
RC STRAIN=972;
RX MEDLINE=95158876; PubMed=7855597;
RA Szankasi P., Smith G.R.;
RT "A role for exonuclease I from S. pombe in mutation avoidance and
RT mismatch correction.";
RL Science 267:1166-1169(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, AND SUBUNIT.
RX MEDLINE=92147644; PubMed=1737756;
RA Szankasi P., Smith G.R.;
RT "A DNA exonuclease induced during meiosis of Schizosaccharomyces
RT pombe.";
RL J. Biol. Chem. 267:3014-3023(1992).
Feature:
CHAIN 1 571 Exodeoxyribonuclease 1.
/FTId=PRO_0000154044.
REGION 1 96 N-domain.
REGION 114 245 I-domain.
Comments:
-!- FUNCTION: 5'->3' double-stranded DNA exonuclease that could act in
a pathway that corrects mismatched base pairs.
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- INDUCTION: By meiosis.
-!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. EXO1
subfamily.
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Sequence length: 571
MGIKGLLGLL KPMQKSSHVE EFSGKTLGVD GYVWLHKAVF TCAHELAFNK ETDKYLKYAI
HQALMLQYYG VKPLIVFDGG PLPCKASTEQ KRKERRQEAF ELGKKLWDEG KKSQAIMQFS
RCVDVTPEMA WKLIIALREH GIESIVAPYE ADAQLVYLEK ENIIDGIITE DSDMLVFGAQ
TVLFKMDGFG NCITIRRNDI ANAQDLNLRL PIEKLRHMAI FSGCDYTDGV AGMGLKTALR
YLQKYPEPRA AIRAMRLDKS LKVPVSFEKE FALADLAFRH QRVYCPKDKT LVHLSPPERE
LSVHEDAFIG SFFDNQLAID IAEGRSNPIT KCAFDIKDSS MQSFTKTTIT ISKRKGISKT
DISNFFMKSI PPSKRPTKST SLIDVTNVKV QRTHLANDIS SEKQSIKSAN EKAYVTPKSN
SLKPGFGKSL SDISNSATKN ENVPFLPPRT GVSKYFKLQK NTEKEIDEQV PSQSNNTTPT
SAKSDSASPQ NWFSSFSYQT PNSASPPFSS LSHTLPISAL AKIGHDALNR KNHASLPSRR
IVYKPPSSPS TPISMNPRPK GILSLQQYKF R