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Description:
Casein kinase I homolog hhp1 (EC 2.7.1.-).
Molecular weight: 42450
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
07-MAR-2006, entry version 43.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein HHP1_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U10863 | AAA21544.1 | - |
| EMBL | X78871 | CAA55473.1 | - |
| EMBL | AL031261 | CAA20311.1 | - |
| PIR | S46357 | S46357. | |
| HSSP | Q06486 | 1CKI | |
| SMR | P40235 | 3-294.1 | |
| GeneDB_Spombe | SPBC3H7.15 | -.1 | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-003840-MONOMER | -.1 | |
| GO | GO:0004674 | F:protein serine/threonine kinase activity | TAS. |
| GO | GO:0006281 | P:DNA repair | IMP. |
| GO | GO:0006468 | P:protein amino acid phosphorylation | TAS. |
| InterPro | IPR000719 | Prot_kinase. | |
| InterPro | IPR008271 | Ser_thr_pkin_AS. | |
| InterPro | IPR002290 | Ser_thr_pkinase. | |
| InterPro | IPR001245 | Tyr_pkinase. | |
| Pfam | PF00069 | Pkinase | 1. |
| ProDom | PD000001 | Prot_kinase | 1. |
| PROSITE | PS00107 | PROTEIN_KINASE_ATP | 1. |
| PROSITE | PS50011 | PROTEIN_KINASE_DOM | 1. |
| PROSITE | PS00108 | PROTEIN_KINASE_ST | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; Kinase; Nuclear protein; Nucleotide-binding; Serine/threonine-protein kinase; Transferase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SP66;
RX MEDLINE=94354807; PubMed=8074660;
RA Kearney P., Ebert M., Kuret J.;
RT "Molecular cloning and sequence analysis of two novel fission yeast
RT casein kinase-1 isoforms.";
RL Biochem. Biophys. Res. Commun. 203:231-236(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX MEDLINE=94298768; PubMed=8026462;
RA Dhillon N., Hoekstra M.F.;
RT "Characterization of two protein kinases from Schizosaccharomyces
RT pombe involved in the regulation of DNA repair.";
RL EMBO J. 13:2777-2788(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 365 Casein kinase I homolog hhp1.
/FTId=PRO_0000192864.
DOMAIN 11 279 Protein kinase.
NP_BIND 17 25 ATP (By similarity).
COMPBIAS 299 323 Gln/Pro-rich.
ACT_SITE 130 130 Proton acceptor (By similarity).
BINDING 40 40 ATP (By similarity).
Comments:
-!- FUNCTION: Involved in DNA repair. Has a probable role in repairing
alkylated DNA and may regulate the activity of protein(s) involved
in double strand break repair caused by gamma rays.
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- SIMILARITY: Belongs to the Ser/Thr protein kinase family. Casein
kinase I subfamily.
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Sequence length: 365
MALDLRIGNK YRIGRKIGSG SFGDIYLGTN VVSGEEVAIK LESTRAKHPQ LEYEYRVYRI
LSGGVGIPFV RWFGVECDYN AMVMDLLGPS LEDLFNFCNR KFSLKTVLLL ADQLISRIEF
IHSKSFLHRD IKPDNFLMGI GKRGNQVNII DFGLAKKYRD HKTHLHIPYR ENKNLTGTAR
YASINTHLGI EQSRRDDLES LGYVLVYFCR GSLPWQGLKA TTKKQKYEKI MEKKISTPTE
VLCRGFPQEF SIYLNYTRSL RFDDKPDYAY LRKLFRDLFC RQSYEFDYMF DWTLKRKTQQ
DQQHQQQLQQ QLSATPQAIN PPPERSSFRN YQKQNFDEKG GDINTTVPVI NDPSATGAQY
INRPN