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Description:
Checkpoint protein hus1.
Molecular weight: 32714
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
07-MAR-2006, entry version 35.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein HUS1_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Y09438 | CAA70588.1 | - |
| EMBL | Z98600 | CAB11254.1 | - |
| PIR | T43396 | T43396. | |
| IntAct | P78955 | -.1 | |
| GeneDB_Spombe | SPAC20G4.04c | -.1 | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-002817-MONOMER | -.1 | |
| GO | GO:0030896 | C:checkpoint clamp complex | IDA. |
| GO | GO:0005515 | F:protein binding | IPI. |
| GO | GO:0000077 | P:DNA damage checkpoint | TAS. |
| GO | GO:0000076 | P:DNA replication checkpoint | TAS. |
| InterPro | IPR007150 | Hus1. | |
| PANTHER | PTHR12900 | Hus.1 | 1. |
| Pfam | PF04005 | Hus1 | 1. |
Keywords:
Cell cycle; Cell division; Complete proteome; DNA damage; DNA repair; Mitosis; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=97324587; PubMed=9180692; DOI=10.1007/s004380050431;
RA Kostrub C.F., Al-Khodairy F., Ghazizadeh H., Carr A.M., Enoch T.;
RT "Molecular analysis of hus1+, a fission yeast gene required for S-M
RT and DNA damage checkpoints.";
RL Mol. Gen. Genet. 254:389-399(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 287 Checkpoint protein hus1.
/FTId=PRO_0000084096.
Comments:
-!- FUNCTION: Essential in controlling the S-M checkpoint that couples
mitosis to the completion of DNA replication. It is also required
for the response to DNA damage. Mutants defective in hus1 have a
nucleus that is cleaved by the septum or the septum divides the
cell into a nucleate and anucleate compartment.
-!- INTERACTION:
Q10159:myh1; NbExp=2; IntAct=EBI-767597, EBI-767574;
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- SIMILARITY: Belongs to the HUS1 family.
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Sequence length: 287
MRFKTRISNL YTLTRLVQAL DKIGRFCWLR LMPETVNFVI VPDFRMTQVW SVLEVETIFE
DYVVQSNADN VINLEVPIDN FYKALRSAAN ASDSTVRLSK KNNQPLLSLS TTWSGRAFGS
NIVTHNIPVR VLSQSYVSVI KEPTAPEPDC HIFLPQLNFL RHVVDKYKSL SDRIIMSANM
SGELQLSVNI PSARVSTKWK GLENPELDPS QVEDISRHPS QTRAPEEFVH MRLDSKDLVN
MLKISSVAKR VIACFCEGHA LVLYVYITDP EDEHTAVLTY YISTYVD