Description:
Telomere length regulator taz1.
Molecular weight: 74647
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
double-strand break repair( GO:0006302 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
07-FEB-2006, entry version 44.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein TAZ1_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Y09406 | CAA70568.1 | - |
| EMBL | Z97185 | CAB10000.1 | - |
| PIR | T37772 | T37772. | |
| GeneDB_Spombe | SPAC16A10.07c | -.1 | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-001675-MONOMER | -.1 | |
| GO | GO:0005724 | C:nuclear telomeric heterochromatin | IDA. |
| GO | GO:0005515 | F:protein binding | IPI. |
| GO | GO:0042803 | F:protein homodimerization activity | IPI. |
| GO | GO:0042162 | F:telomeric DNA binding | IDA. |
| GO | GO:0006348 | P:chromatin silencing at telomere | IMP. |
| GO | GO:0007059 | P:chromosome segregation | IMP. |
| GO | GO:0000077 | P:DNA damage checkpoint | IMP. |
| GO | GO:0006302 | P:double-strand break repair | IMP. |
| GO | GO:0007131 | P:meiotic recombination | IMP. |
| GO | GO:0007095 | P:mitotic G2 checkpoint | IMP. |
| GO | GO:0008104 | P:protein localization | IGI. |
| GO | GO:0007004 | P:telomerase-dependent telomere maintenance | TAS. |
| GO | GO:0045141 | P:telomere clustering | IMP. |
| InterPro | IPR012287 | Homeodomain-rel. | |
| InterPro | IPR001005 | Myb_DNA_bd. | |
| Pfam | PF00249 | Myb_DNA-binding | 1. |
| SMART | SM00717 | SANT | 1. |
| PROSITE | PS00037 | MYB_1 | 1. |
| PROSITE | PS00334 | MYB_2 | FALSE_NEG. |
| PROSITE | PS50090 | MYB_3 | FALSE_NEG. |
Keywords:
Chromosomal protein; Complete proteome; DNA-binding; Nuclear protein; Repeat; Telomere.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=972;
RX MEDLINE=97186578; PubMed=9034194; DOI=10.1038/385744a0;
RA Cooper J.P., Nimmo E.R., Allshire R.C., Cech T.R.;
RT "Regulation of telomere length and function by a Myb-domain protein in
RT fission yeast.";
RL Nature 385:744-747(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP INTERACTION WITH TAF1.
RX MEDLINE=21169636; PubMed=11270572; DOI=10.1007/s002940000168;
RA Ueno M., Kurokawa R., Renauld H., Watanabe K., Ushimaru T.,
RA Uritani M., Yoshinaga K., Hiraoka Y.;
RT "Schizosaccharomyces pombe taf1+ is required for nitrogen starvation-
RT induced sexual development and for entering the dormant GO state.";
RL Curr. Genet. 38:307-313(2001).
Feature:
CHAIN 1 663 Telomere length regulator taz1.
/FTId=PRO_0000197124.
DNA_BIND 556 612 Myb.
Comments:
-!- FUNCTION: Regulates telomere length and function. Required for the
repression of telomere-adjacent gene expression and for normal
meiosis or sporulation. It may be a negative regulator of the
telomere-replicating enzyme, telomerase, or may protect against
activation of telomerase-independent patways of telomere
elongation. It may be involved in the interactions between
chromosomes and spindle proteins, disruption of these interactions
would lead to defective meiosis.
-!- SUBUNIT: Interacts with taf1 via the Myb domain.
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- SIMILARITY: Contains 1 Myb DNA-binding domain.
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Sequence length: 663
MISVQSTETI QKVLENEGDQ QFDKEVVQNS DSNIETGQIS DSLTKAVEER AETESSSNLS
NFTTSESESS KPAYCFNSHS QNMAEGSISI PVISHSMNVE NEVSTAEGQD SRTGESENDQ
NAMIVRSIWD IEKASLLVND CQNIANMAEQ KVMMVSAIFS ESSKDIVNPE SFSERLGKET
VKDLYEFNEQ LTTKYGLEFR TIFFSYIRKY DAYWCLFEDL EKPLKSIQFF TGLIDLLDNT
NKHLTLRSIV LDALLSADEE DSFYGDALVL FEELVIRYFG TDSNPSIDAS EFILSCLPYT
SLDALNVVCG QVWKSQKICD FLKSTIGNTS NSPLQLRASF PAFVNAVIHF LLEFKNVRRL
ERKDLSVKGM LYDSDSQQIL NRLRERVSGS TAQSADEASG HESDASEDTF SERTLGLNSI
DNTEISEVVS LGLVSSALDK ITGLLSADNL SETVSQARDF SHTLSKSLKS RAKSLSQKEA
ANRSKLIAKR GDNLRREASL SSEQDDLSED FPPVRESDEQ ESRSGGRSSA MRVSIERSAA
RSGTRRSQGN PYEGYRTRRK WTDEEENELY EMISQHGCCW SKIIHIQKLE NGPLKTFGPT
QIKDKARLIK ARFMKQNRLQ ELYSKSLNWK NVTVGQAYCE LHKIPYIEAT PPLLREELVN
YQS