Description:
G/U mismatch-specific uracil DNA glycosylase (EC 3.2.2.-) (Uracilmismatch repair protein).
Molecular weight: 36574
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
07-FEB-2006, entry version 34.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein TDG_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AJ277958 | CAB93678.1 | - |
| EMBL | AF288481 | AAG01021.1 | - |
| EMBL | AL023590 | CAA19065.1 | - |
| PIR | T41658 | T41658. | |
| GeneDB_Spombe | SPCC965.05c | -.1 | |
| BioCyc | SPOM-XXX-01:SPOM-XXX-01-000416-MONOMER | -.1 | |
| GO | GO:0004844 | F:uracil DNA N-glycosylase activity | IDA. |
| InterPro | IPR003310 | G:TDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| Pfam | PF03167 | UDG | 1. |
| TIGRFAMs | TIGR00584 | mug | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Nuclear protein.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=972;
RX MEDLINE=22598200; PubMed=12711670; DOI=10.1093/nar/gkg344;
RA Hardeland U., Bentele M., Jiricny J., Schaer P.;
RT "The versatile thymine DNA-glycosylase: a comparative characterization
RT of the human, Drosophila and fission yeast orthologs.";
RL Nucleic Acids Res. 31:2261-2271(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zhu X., Zhao Y.;
RT "An ortholog of thymine mismatch repair enzyme gene in
RT Schizosaccharomyces pombe.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 325 G/U mismatch-specific uracil DNA
glycosylase.
/FTId=PRO_0000185779.
Comments:
-!- FUNCTION: Removes uracil from G/U mispairs in ssDNA. Also corrects
G/G mispairs. Does not catalyze the removal of thymine from G/T
mispairs.
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- SIMILARITY: Belongs to the TDG/mug DNA glycosylase family.
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Sequence length: 325
MNDIETRDTG TKNDNSSEFN LSVKSHKRKR SFDDENLELE ESREETSGGI LKKAKTQSFS
ESLERFRFAH AGSNNEYRKT DVVKNSDTDN GLLKSAVETI TLENGLRNRR VNVTKKSTLK
ASVKKSTLKK KNEVDPALLQ GVPDYICENP YAIIVGLNPG ITSSLKGHAF ASPSNRFWKM
LNKSKLLEGN AEFTYLNDKD LPAHGLGITN LCARPSSSGA DLRKEEMQDG ARILYEKVKR
YRPQVGLFIS GKGIWEEMYK MLTGKKLPKT FVFGWQPEKF GDANVFVGIS SSGRAAGYSD
EKKQNLWNLF AEEVNRHREI VKHAV