Description:
Ubiquitin.
Molecular weight: 8557 M
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
21-JUN-2005, sequence version 1.
21-FEB-2006, entry version 9.
Phylogenetic order:
Eukaryota Fungi Ascomycota Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UBIQ_SCHPO:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Z99161 | CAB16209.1 | ALT_TERM |
| EMBL | AL117390 | CAB55853.1 | ALT_TERM |
| EMBL | Z98603 | CAB11297.1 | ALT_TERM |
| EMBL | AL031854 | CAA21278.1 | ALT_TERM |
| PIR | T37547 | T37547. | |
| PIR | T39061 | T39061. | |
| HSSP | Q862M4 | 1AAR | |
| SMR | P0C014 | 1-76.1 | |
| GeneDB_Spombe | SPAC11G7.04 | -.1 | |
| GeneDB_Spombe | SPAC1805.12c | -.1 | |
| GeneDB_Spombe | SPAC6G10.11c | -.1 | |
| GeneDB_Spombe | SPBC337.08c | -.1 | |
| GO | GO:0007126 | P:meiosis | IMP. |
| InterPro | IPR000626 | Ubiquitin. | |
| Pfam | PF00240 | ubiquitin | 1. |
| PRINTS | PR00348 | UBIQUITIN. | |
| SMART | SM00213 | UBQ | 1. |
| PROSITE | PS00299 | UBIQUITIN_1 | 1. |
| PROSITE | PS50053 | UBIQUITIN_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Nuclear protein; Polyprotein; Ubl conjugation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972;
RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
Feature:
CHAIN 1 76 Ubiquitin.
/FTId=PRO_0000114860.
CROSSLNK 29 29 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in
multiubiquitin) (By similarity).
CROSSLNK 48 48 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in
multiubiquitin) (By similarity).
CROSSLNK 63 63 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in
multiubiquitin) (By similarity).
CROSSLNK 76 76 Glycyl lysine isopeptide (Gly-Lys)
(interchain with K-? in acceptor
proteins) (By similarity).
Comments:
-!- FUNCTION: Involved in the ATP-dependent selective degradation of
cellular proteins, the maintenance of chromatin structure, the
regulation of gene expression, the stress response, and ribosome
biogenesis and DNA repair.
-!- SUBCELLULAR LOCATION: Nuclear and cytoplasmic.
-!- MISCELLANEOUS: Ubi1 and ubi2 are synthesized as a polyprotein with
one copy of ubiquitin fused to ribosomal protein L40. Ubi3 is a
polyprotein with one copy of ubiquitin fused to ribosomal protein
S27a. Ubi4 is a polyprotein containing 5 exact head to tail
repeats of ubiquitin, there is an additional Leu-Phe after the
last repeat.
-!- SIMILARITY: Belongs to the ubiquitin family.
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Sequence length: 76
MQIFVKTLTG KTITLEVESS DTIDNVKSKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
IQKESTLHLV LRLRGG