Description:
Uracil-DNA glycosylase (EC 3.2.2.-) (UDG).
Molecular weight: 24588
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
07-MAR-2006, entry version 34.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Neisseriales Neisseriaceae Neisseria.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_NEIMB:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AE002098 | AAF41604.1 | - |
| PIR | H81107 | H81107. | |
| HSSP | P12295 | 3EUG | |
| GenomeReviews | AE002098_GR | NMB1222.1 | |
| TIGR | NMB1222 | -. | |
| BioCyc | NMEN491:NMB1222-MONOMER | -.1 | |
| HAMAP | MF_00148 | - | 1. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 / Serogroup B;
RX MEDLINE=20175755; PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J.F., Jeffries A.C.,
RA Nelson K.E., Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F.,
RA Dodson R.J., Nelson W.C., Gwinn M.L., DeBoy R.T., Peterson J.D.,
RA Hickey E.K., Haft D.H., Salzberg S.L., White O., Fleischmann R.D.,
RA Dougherty B.A., Mason T.M., Ciecko A., Parksey D.S., Blair E.,
RA Cittone H., Clark E.B., Cotton M.D., Utterback T.R., Khouri H.M.,
RA Qin H., Vamathevan J.J., Gill J., Scarlato V., Masignani V., Pizza M.,
RA Grandi G., Sun L., Smith H.O., Fraser C.M., Moxon E.R., Rappuoli R.,
RA Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
Feature:
CHAIN 1 219 Uracil-DNA glycosylase.
/FTId=PRO_0000176122.
ACT_SITE 61 61 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 219
MDTWHDALGG EKQQPYFQEI LNAVRQERLS GQIIYPPAAD VFNAFRLTAF DRVKAVILGQ
DPYHGAGQAH GLAFSVRQGI RIPPSLLNIY KELETDIEGF SIPAHGCLTA WAEQGVLLLN
TVLTVRAGQA HSHALLGWER FTDTVIRQLA THRKHLVFML WGGYAQQKGR LIDSQNHLIL
TAPHPSPLSA YRGFFGCRHF SQANSYLSRH GIDPINWKL