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Description:
Protein BDF1.
Molecular weight: 76978
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
15-JUL-1999, sequence version 3.
07-MAR-2006, entry version 46.
Phylogenetic order:
Eukaryota Fungi Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein BDF1_YEAST:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | Z18944 | CAA79377.1 | - |
| EMBL | U18116 | AAA89115.1 | - |
| EMBL | U19729 | AAB82357.1 | - |
| EMBL | L13469 | AAA35048.1 | - |
| PIR | S55955 | S55955. | |
| HSSP | Q03330 | 1E6I | |
| IntAct | P35817 | -.1 | |
| GermOnline | 142462 | -.1 | |
| TRANSFAC | T03204 | -. | |
| Ensembl | YLR399C | Saccharomyces cerevisiae.1 | |
| GenomeReviews | Y13138_GR | YLR399C.1 | |
| SGD | S000004391 | BDF1. | |
| BioCyc | SCER-S28-01:SCER-S28-01-004290-MONOMER | -.1 | |
| LinkHub | P35817 | -.1 | |
| GO | GO:0000790 | C:nuclear chromatin | IDA. |
| GO | GO:0005634 | C:nucleus | IDA. |
| GO | GO:0005515 | F:protein binding | IPI. |
| GO | GO:0030528 | F:transcription regulator activity | IMP. |
| GO | GO:0006338 | P:chromatin remodeling | IPI. |
| GO | GO:0006281 | P:DNA repair | IMP. |
| GO | GO:0007126 | P:meiosis | IMP. |
| GO | GO:0030437 | P:sporulation (sensu Fungi) | IMP. |
| InterPro | IPR001487 | Bromodomain. | |
| Pfam | PF00439 | Bromodomain | 2. |
| PRINTS | PR00503 | BROMODOMAIN. | |
| SMART | SM00297 | BROMO | 2. |
| PROSITE | PS00633 | BROMODOMAIN_1 | 2. |
| PROSITE | PS50014 | BROMODOMAIN_2 | 2. |
Keywords:
Bromodomain; Complete proteome; Nuclear protein; Repeat; Sporulation; Transcription; Transcription regulation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S288c;
RX MEDLINE=95116323; PubMed=7816623;
RA Lygerou Z., Conesa C., Lesage P., Swanson R.N., Ruet A., Carlson M.,
RA Sentenac A., Seraphin B.;
RT "The yeast BDF1 gene encodes a transcription factor involved in the
RT expression of a broad class of genes including snRNAs.";
RL Nucleic Acids Res. 22:5332-5340(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Roeder G.S., Chua P.R.;
RL Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S288c / AB972;
RX MEDLINE=97313267; PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B.,
RA Ansorge W., Benes V., Brueckner M., Delius H., Dubois E.,
RA Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U.,
RA Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K.,
RA Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T.,
RA Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E.,
RA Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M.,
RA Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C.,
RA Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M.,
RA Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H.,
RA Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A.,
RA Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE OF 471-686.
RX MEDLINE=93309467; PubMed=8321235;
RA Widner W.R., Wickner R.B.;
RT "Evidence that the SKI antiviral system of Saccharomyces cerevisiae
RT acts by blocking expression of viral mRNA.";
RL Mol. Cell. Biol. 13:4331-4341(1993).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION.
RX MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA Dephoure N., O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
Feature:
CHAIN 1 686 Protein BDF1.
/FTId=PRO_0000211176.
DOMAIN 165 237 Bromo 1.
DOMAIN 332 404 Bromo 2.
DOMAIN 522 686 ET.
CONFLICT 8 8 Q -> LC (in Ref. 1).
CONFLICT 93 94 GA -> R (in Ref. 2).
CONFLICT 94 94 A -> P (in Ref. 2).
CONFLICT 282 282 A -> P (in Ref. 1).
CONFLICT 385 385 D -> E (in Ref. 1).
CONFLICT 493 493 A -> R (in Ref. 4).
Comments:
-!- FUNCTION: Transcription factor involved in the expression of a
broad class of genes including snRNAs. Required for sporulation.
-!- INTERACTION:
Q07442:BDF2; NbExp=1; IntAct=EBI-3493, EBI-37620;
-!- SUBCELLULAR LOCATION: Nucleus (Probable).
-!- MISCELLANEOUS: Present with 8100 molecules/cell.
-!- SIMILARITY: Contains 2 bromo domains.
-!- SIMILARITY: Contains 1 ET domain.
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Sequence length: 686
MTDITPVQND VDVNGNNVND DVSSNLKRPI DQGDPSNGLA EEENPANNQL HLKKARLDGD
ALTSSPAGLA ENGIEGATLA ANGENGYNAT GSGAEDEQQG LKKEEGGQGT KQEDLDENSK
QELPMEVPKE PAPAPPPEPD MNNLPQNPIP KHQQKHALLA IKAVKRLKDA RPFLQPVDPV
KLDIPFYFNY IKRPMDLSTI ERKLNVGAYE VPEQITEDFN LMVNNSIKFN GPNAGISQMA
RNIQASFEKH MLNMPAKDAP PVIAKGRRSS AQEDAPIVIR RAQTHNGRPK RTIHPPKSKD
IYPYESKKPK SKRLQQAMKF CQSVLKELMA KKHASYNYPF LEPVDPVSMN LPTYFDYVKE
PMDLGTIAKK LNDWQYQTME DFERDVRLVF KNCYTFNPDG TIVNMMGHRL EEVFNSKWAD
RPNLDDYDSD EDSRTQGDYD DYESEYSESD IDETIITNPA IQYLEEQLAR MKVELQQLKK
QELEKIRKER RLARGSKKRG KRSKGRSGSK NASSKGRRDK KNKLKTVVTY DMKRIITERI
NDLPTSKLER AIDIIKKSMP NISEDDEVEL DLDTLDNHTI LTLYNTFFRQ YESSSGASNG
LDGTSGVTRD ASSLSPTSAG SRKRRSKALS QEEQSRQIEK IKNKLAILDS ASPLSQNGSP
GQIQSAAHNG FSSSSDDDVS SESEEE