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Description:
DNA damage-inducible protein DIN7.
Molecular weight: 49034
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
07-MAR-2006, entry version 50.
Phylogenetic order:
Eukaryota Fungi Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DIN7_YEAST:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X90707 | CAA62233.1 | - |
| EMBL | Z70202 | CAA94102.1 | - |
| EMBL | Z68290 | CAA92581.1 | - |
| PIR | S61118 | S61118. | |
| GermOnline | 140755 | -.1 | |
| Ensembl | YDR263C | Saccharomyces cerevisiae.1 | |
| GenomeReviews | Z71256_GR | YDR263C.1 | |
| SGD | S000002671 | DIN7. | |
| BioCyc | SCER-S28-01:SCER-S28-01-001284-MONOMER | -.1 | |
| LinkHub | Q12086 | -.1 | |
| GO | GO:0005739 | C:mitochondrion | IDA. |
| GO | GO:0006281 | P:DNA repair | IDA. |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR006086 | XPG_I. | |
| InterPro | IPR006085 | XPG_N. | |
| InterPro | IPR006084 | XPGC_Rad. | |
| Pfam | PF00867 | XPG_I | 1. |
| Pfam | PF00752 | XPG_N | 1. |
| PRINTS | PR00853 | XPGRADSUPER. | |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00484 | XPGI | 1. |
| SMART | SM00485 | XPGN | 1. |
| PROSITE | PS00841 | XPG_1 | 1. |
| PROSITE | PS00842 | XPG_2 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclear protein; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=OL1;
RX MEDLINE=97234602; PubMed=9079876; DOI=10.1007/s004380050369;
RA Mieczkowski P.A., Fikus M., Ciesla Z.;
RT "Characterization of a novel DNA damage-inducible gene of
RT Saccharomyces cerevisiae, DIN7, which is a structural homolog of the
RT RAD2 and RAD27 DNA repair genes.";
RL Mol. Gen. Genet. 253:655-665(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S288c / AB972;
RX MEDLINE=97313263; PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
RA Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
RA Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
RA Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
RA Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
RA Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
RA Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
RA Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
RA Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
RA Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
RA Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
RA Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
RA Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
RA Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
RA Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
RA Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
RA Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
RA Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
RA Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
RA Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
RA Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
RA Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
RA Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
Feature:
CHAIN 1 430 DNA damage-inducible protein DIN7.
/FTId=PRO_0000154046.
REGION 1 96 N-domain.
REGION 114 247 I-domain.
Comments:
-!- FUNCTION: 5'->3' double-stranded DNA exonuclease (By similarity).
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- INDUCTION: By UV light, methyl methane-sulfonate (MMS) or
hydroxyurea (HU), and during meiosis.
-!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family.
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Sequence length: 430
MGIPGLLPQL KRIQKQVSLK KYMYQTLAID GYAWLHRASC ACAFELVMNK PTNKYLQFFI
KRLQLLKRLK IKPYIVFDGD SLFVKNHTET RRRKKRLENE MIAKKLWSAG NRYNAMEYFQ
KSVDITPEMA KCIIDYCKLH SIPYIVAPFE ADPQMVYLEK MGLIQGIISE DSDLLVFGCK
TLITKLNDQG KALEISKDDF SALPENFPLG ELSEQQFRNL VCLAGCDYTS GIWKVGVVTA
MKIVKRYSEM KDILIQIERT EKLCFSKAFK QQVEFANYAF QYQRVFCPLS NQITTLNNIP
KAVTNSHAEI IKIMKCIGSV VERGSGVRKD VINTKNIDHK VHEMIAKGEL HPVDMASKLI
NRERKLKARK LFKVGLLGGE SNSFNKKVEQ PLVDTQDVLS ERENSLDNKN ASSIYMTSPA
AISGTVPSIF