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Description:
DNA replication ATP-dependent helicase DNA2 (EC 3.6.1.-).
Molecular weight: 1716
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Eukaryota Fungi Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DNA2_YEAST:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U00027 | AAB68010.1 | - |
| PIR | S48904 | S48904. | |
| IntAct | P38859 | -.1 | |
| GermOnline | 139482 | -.1 | |
| Ensembl | YHR164C | Saccharomyces cerevisiae.1 | |
| GenomeReviews | U00093_GR | YHR164C.1 | |
| SGD | S000001207 | DNA2. | |
| BioCyc | SCER-S28-01:SCER-S28-01-002799-MONOMER | -.1 | |
| LinkHub | P38859 | -.1 | |
| GO | GO:0000784 | C:nuclear chromosome, telomeric region | IDA. |
| GO | GO:0005634 | C:nucleus | TAS. |
| GO | GO:0017108 | F:5'-flap endonuclease activity | IDA. |
| GO | GO:0004003 | F:ATP-dependent DNA helicase activity | IDA. |
| GO | GO:0000014 | F:single-stranded DNA specific endodeoxyribon... | IDA. |
| GO | GO:0006281 | P:DNA repair | IGI. |
| GO | GO:0006261 | P:DNA-dependent DNA replication | IDA. |
| GO | GO:0006273 | P:lagging strand elongation | IGI. |
| GO | GO:0001302 | P:replicative cell aging | IMP. |
| GO | GO:0000723 | P:telomere maintenance | IMP. |
Keywords:
ATP-binding; Complete proteome; DNA replication; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S288c / AB972;
RX MEDLINE=94378003; PubMed=8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J.,
RA Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J.,
RA Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y.,
RA Latreille P., Louis E.J., Macri C., Mardis E., Menezes S., Mouser L.,
RA Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K.,
RA Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R.,
RA Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP CHARACTERIZATION.
RX MEDLINE=95372336; PubMed=7644470;
RA Budd M.E., Campbell J.L.;
RT "A yeast gene required for DNA replication encodes a protein with
RT homology to DNA helicases.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:7642-7646(1995).
Feature:
CHAIN 1 1522 DNA replication ATP-dependent helicase
DNA2.
/FTId=PRO_0000080711.
NP_BIND 1074 1081 ATP (By similarity).
Comments:
-!- FUNCTION: Required for DNA replication; has 3' to 5' ATP-dependent
DNA helicase activity specific for forked substrates.
-!- INTERACTION:
P26793:RAD27; NbExp=1; IntAct=EBI-5973, EBI-14693;
-!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family.
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Sequence length: 1522
MPGTPQKNKR SASISVSPAK KTEEKEIIQN DSKAILSKQT KRKKKYAFAP INNLNGKNTK
VSNASVLKSI AVSQVRNTSR TKDINKAVSK SVKQLPNSQV KPKREMSNLS RHHDFTQDED
GPMEEVIWKY SPLQRDMSDK TTSAAEYSDD YEDVQNPSST PIVPNRLKTV LSFTNIQVPN
ADVNQLIQEN GNEQVRPKPA EISTRESLRN IDDILDDIEG DLTIKPTITK FSDLPSSPIK
APNVEKKAEV NAEEVDKMDS TGDSNDGDDS LIDILTQKYV EKRKSESQIT IQGNTNQKSG
AQESCGKNDN TKSRGEIEDH ENVDNQAKTG NAFYENEEDS NCQRIKKNEK IEYNSSDEFS
DDSLIELLNE TQTQVEPNTI EQDLDKVEKM VSDDLRIATD STLSAYALRA KSGAPRDGVV
RLVIVSLRSV ELPKIGTQKI LECIDGKGEQ SSVVVRHPWV YLEFEVGDVI HIIEGKNIEN
KRLLSDDKNP KTQLANDNLL VLNPDVLFSA TSVGSSVGCL RRSILQMQFQ DPRGEPSLVM
TLGNIVHELL QDSIKYKLSH NKISMEIIIQ KLDSLLETYS FSIIICNEEI QYVKELVMKE
HAENILYFVN KFVSKSNYGC YTSISGTRRT QPISISNVID IEENIWSPIY GLKGFLDATV
EANVENNKKH IVPLEVKTGK SRSVSYEVQG LIYTLLLNDR YEIPIEFFLL YFTRDKNMTK
FPSVLHSIKH ILMSRNRMSM NFKHQLQEVF GQAQSRFELP PLLRDSSCDS CFIKESCMVL
NKLLEDGTPE ESGLVEGEFE ILTNHLSQNL ANYKEFFTKY NDLITKEESS ITCVNKELFL
LDGSTRESRS GRCLSGLVVS EVVEHEKTEG AYIYCFSRRR NDNNSQSMLS SQIAANDFVI
ISDEEGHFCL CQGRVQFINP AKIGISVKRK LLNNRLLDKE KGVTTIQSVV ESELEQSSLI
ATQNLVTYRI DKNDIQQSLS LARFNLLSLF LPAVSPGVDI VDERSKLCRK TKRSDGGNEI
LRSLLVDNRA PKFRDANDDP VIPYKLSKDT TLNLNQKEAI DKVMRAEDYA LILGMPGTGK
TTVIAEIIKI LVSEGKRVLL TSYTHSAVDN ILIKLRNTNI SIMRLGMKHK VHPDTQKYVP
NYASVKSYND YLSKINSTSV VATTCLGIND ILFTLNEKDF DYVILDEASQ ISMPVALGPL
RYGNRFIMVG DHYQLPPLVK NDAARLGGLE ESLFKTFCEK HPESVAELTL QYRMCGDIVT
LSNFLIYDNK LKCGNNEVFA QSLELPMPEA LSRYRNESAN SKQWLEDILE PTRKVVFLNY
DNCPDIIEQS EKDNITNHGE AELTLQCVEG MLLSGVPCED IGVMTLYRAQ LRLLKKIFNK
NVYDGLEILT ADQFQGRDKK CIIISMVRRN SQLNGGALLK ELRRVNVAMT RAKSKLIIIG
SKSTIGSVPE IKSFVNLLEE RNWVYTMCKD ALYKYKFPDR SNAIDEARKG CGKRTGAKPI
TSKSKFVSDK PIIKEILQEY ES