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Description:
DNA polymerase zeta catalytic subunit (EC 2.7.7.7).
Molecular weight: 1729
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
01-JAN-1990, sequence version 1.
07-MAR-2006, entry version 57.
Phylogenetic order:
Eukaryota Fungi Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DPOZ_YEAST:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M29683 | AAA34968.1 | - |
| EMBL | X96770 | CAA65554.1 | - |
| EMBL | Z73523 | CAA97873.1 | - |
| PIR | A33602 | A33602. | |
| GermOnline | 144149 | -.1 | |
| Ensembl | YPL167C | Saccharomyces cerevisiae.1 | |
| GenomeReviews | U00094_GR | YPL167C.1 | |
| SGD | S000006088 | REV3. | |
| BioCyc | SCER-S28-01:SCER-S28-01-006023-MONOMER | -.1 | |
| LinkHub | P14284 | -.1 | |
| GO | GO:0016035 | C:zeta DNA polymerase complex | IDA. |
| GO | GO:0003894 | F:zeta DNA polymerase activity | IDA. |
| GO | GO:0006281 | P:DNA repair | TAS. |
| GO | GO:0006280 | P:mutagenesis | TAS. |
| InterPro | IPR006172 | DNA_pol_B. | |
| InterPro | IPR006133 | DNA_pol_B_exo. | |
| InterPro | IPR006134 | DNA_pol_B_region. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| Pfam | PF00136 | DNA_pol_B | 1. |
| Pfam | PF03104 | DNA_pol_B_exo | 1. |
| PRINTS | PR00106 | DNAPOLB. | |
| SMART | SM00486 | POLBc | 1. |
| PROSITE | PS00116 | DNA_POLYMERASE_B | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; DNA replication; DNA-binding; DNA-directed DNA polymerase; Metal-binding; Nuclear protein; Nucleotidyltransferase; Transferase; Zinc; Zinc-finger.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=90008808; PubMed=2676986;
RA Morrison A., Christensen R.B., Alley J., Beck A.K., Bernstine E.G.,
RA Lemontt J.F., Lawrence C.W.;
RT "REV3, a Saccharomyces cerevisiae gene whose function is required for
RT induced mutagenesis, is predicted to encode a nonessential DNA
RT polymerase.";
RL J. Bacteriol. 171:5659-5667(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S288c / AB972;
RX MEDLINE=97103777; PubMed=8948103;
RX DOI=10.1002/(SICI)1097-0061(199611)12:14<1483::AID-YEA34>3.3.CO;2-F;
RA Purnelle B., Coster F., Goffeau A.;
RT "The sequence of 55 kb on the left arm of yeast chromosome XVI
RT identifies a small nuclear RNA, a new putative protein kinase and two
RT new putative regulators.";
RL Yeast 12:1483-1492(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S288c / AB972;
RX MEDLINE=97313271; PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V.,
RA Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M.,
RA Chung E., Churcher C.M., Coster F., Davis K., Davis R.W.,
RA Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A.,
RA Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A.,
RA Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W.,
RA Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K.,
RA Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J.,
RA Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D.,
RA Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V.,
RA Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W.,
RA Zollner A., Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
Feature:
CHAIN 1 1504 DNA polymerase zeta catalytic subunit.
/FTId=PRO_0000046470.
ZN_FING 1398 1417 C4-type (Potential).
ZN_FING 1446 1473 C4-type (Potential).
Comments:
-!- FUNCTION: Required for induced mutagenesis, it is a nonessential
DNA polymerase. It may function in translesion synthesis.
Translesion synthesis in S.cerevisiae may use a specialized DNA
polymerase that is not required for other DNA replicative
processes.
-!- CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) =
diphosphate + DNA(n+1).
-!- SUBCELLULAR LOCATION: Nucleus (Potential).
-!- SIMILARITY: Belongs to the DNA polymerase type-B family.
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Sequence length: 1504
MSRESNDTIQ SDTVRSSSKS DYFRIQLNNQ DYYMSKPTFL DPSHGESLPL NQFSQVPNIR
VFGALPTGHQ VLCHVHGILP YMFIKYDGQI TDTSTLRHQR CAQVHKTLEV KIRASFKRKK
DDKHDLAGDK LGNLNFVADV SVVKGIPFYG YHVGWNLFYK ISLLNPSCLS RISELIRDGK
IFGKKFEIYE SHIPYLLQWT ADFNLFGCSW INVDRCYFRS PVLNSILDID KLTINDDLQL
LLDRFCDFKC NVLSRRDFPR VGNGLIEIDI LPQFIKNREK LQHRDIHHDF LEKLGDISDI
PVKPYVSSAR DMINELTMQR EELSLKEYKE PPETKRHVSG HQWQSSGEFE AFYKKAQHKT
STFDGQIPNF ENFIDKNQKF SAINTPYEAL PQLWPRLPQI EINNNSMQDK KNDDQVNASF
TEYEICGVDN ENEGVKGSNI KSRSYSWLPE SIASPKDSTI LLDHQTKYHN TINFSMDCAM
TQNMASKRKL RSSVSANKTS LLSRKRKKVM AAGLRYGKRA FVYGEPPFGY QDILNKLEDE
GFPKIDYKDP FFSNPVDLEN KPYAYAGKRF EISSTHVSTR IPVQFGGETV SVYNKPTFDM
FSSWKYALKP PTYDAVQKWY NKVPSMGNKK TESQISMHTP HSKFLYKFAS DVSGKQKRKK
SSVHDSLTHL TLEIHANTRS DKIPDPAIDE VSMIIWCLEE ETFPLDLDIA YEGIMIVHKA
SEDSTFPTKI QHCINEIPVM FYESEFEMFE ALTDLVLLLD PDILSGFEIH NFSWGYIIER
CQKIHQFDIV RELARVKCQI KTKLSDTWGY AHSSGIMITG RHMINIWRAL RSDVNLTQYT
IESAAFNILH KRLPHFSFES LTNMWNAKKS TTELKTVLNY WLSRAQINIQ LLRKQDYIAR
NIEQARLIGI DFHSVYYRGS QFKVESFLIR ICKSESFILL SPGKKDVRKQ KALECVPLVM
EPESAFYKSP LIVLDFQSLY PSIMIGYNYC YSTMIGRVRE INLTENNLGV SKFSLPRNIL
ALLKNDVTIA PNGVVYAKTS VRKSTLSKML TDILDVRVMI KKTMNEIGDD NTTLKRLLNN
KQLALKLLAN VTYGYTSASF SGRMPCSDLA DSIVQTGRET LEKAIDIIEK DETWNAKVVY
GDTDSLFVYL PGKTAIEAFS IGHAMAERVT QNNPKPIFLK FEKVYHPSIL ISKKRYVGFS
YESPSQTLPI FDAKGIETVR RDGIPAQQKI IEKCIRLLFQ TKDLSKIKKY LQNEFFKIQI
GKVSAQDFCF AKEVKLGAYK SEKTAPAGAV VVKRRINEDH RAEPQYKERI PYLVVKGKQG
QLLRERCVSP EEFLEGENLE LDSEYYINKI LIPPLDRLFN LIGINVGNWA QEIVKSKRAS
TTTTKVENIT RVGTSATCCN CGEELTKICS LQLCDDCLEK RSTTTLSFLI KKLKRQKEYQ
TLKTVCRTCS YRYTSDAGIE NDHIASKCNS YDCPVFYSRV KAERYLRDNQ SVQREEALIS
LNDW