Description:
Uracil-DNA glycosylase, mitochondrial precursor (EC 3.2.2.-) (UDG).
Molecular weight: 40471
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 )
Important dates:
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
01-OCT-1989, sequence version 1.
07-MAR-2006, entry version 60.
Phylogenetic order:
Eukaryota Fungi Ascomycota Saccharomycotina Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UNG_YEAST:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | J04470 | AAA35195.1 | - |
| EMBL | Z46659 | CAA86634.1 | - |
| PIR | A31425 | A31425. | |
| HSSP | P13051 | 1AKZ | |
| GermOnline | 142554 | -.1 | |
| Ensembl | YML021C | Saccharomyces cerevisiae.1 | |
| GenomeReviews | Z71257_GR | YML021C.1 | |
| SGD | S000004483 | UNG1. | |
| BioCyc | SCER-S28-01:SCER-S28-01-004386-MONOMER | -.1 | |
| LinkHub | P12887 | -.1 | |
| GO | GO:0005739 | C:mitochondrion | IDA. |
| GO | GO:0005634 | C:nucleus | IDA. |
| GO | GO:0004844 | F:uracil DNA N-glycosylase activity | IDA. |
| GO | GO:0006281 | P:DNA repair | IMP. |
| InterPro | IPR003249 | U_glycsylse_notp. | |
| InterPro | IPR002043 | UDNA_glycsylse. | |
| InterPro | IPR005122 | UDNA_glycsylseSF. | |
| PANTHER | PTHR11264 | U_glycsylse_notp.1 | 1. |
| Pfam | PF03167 | UDG | 1. |
| ProDom | PD001589 | U_glycsylse_notp | 1. |
| TIGRFAMs | TIGR00628 | ung | 1. |
| PROSITE | PS00130 | U_DNA_GLYCOSYLASE | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Mitochondrion; Nuclear protein; Transit peptide.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=89123348; PubMed=2644266;
RA Percival K.J., Klein M.B., Burgers P.M.J.;
RT "Molecular cloning and primary structure of the uracil-DNA glycosylase
RT gene from Saccharomyces cerevisiae.";
RL J. Biol. Chem. 264:2593-2598(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S288c / AB972;
RX MEDLINE=97313268; PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S.,
RA Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A.,
RA Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome
RT XIII.";
RL Nature 387:90-93(1997).
RN [3]
RP LEVEL OF PROTEIN EXPRESSION.
RX MEDLINE=22923965; PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
RA Dephoure N., O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
Feature:
TRANSIT 1 ? Mitochondrion (Potential).
CHAIN ? 359 Uracil-DNA glycosylase.
/FTId=PRO_0000036085.
ACT_SITE 162 162 Proton acceptor (By similarity).
Comments:
-!- FUNCTION: Excises uracil residues from the DNA which can arise as
a result of misincorporation of dUMP residues by DNA polymerase or
due to deamination of cytosine.
-!- SUBCELLULAR LOCATION: Nuclear and mitochondrial.
-!- MISCELLANEOUS: Present with 4820 molecules/cell.
-!- SIMILARITY: Belongs to the uracil-DNA glycosylase family.
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Sequence length: 359
MWCMRRLPTN SVMTVARKRK QTTIEDFFGT KKSTNEAPNK KGKSGATFMT ITNGAAIKTE
TKAVAKEANT DKYPANSNAK DVYSKNLSSN LRTLLSLELE TIDDSWFPHL MDEFKKPYFV
KLKQFVTKEQ ADHTVFPPAK DIYSWTRLTP FNKVKVVIIG QDPYHNFNQA HGLAFSVKPP
TPAPPSLKNI YKELKQEYPD FVEDNKVGDL THWASQGVLL LNTSLTVRAH NANSHSKHGW
ETFTKRVVQL LIQDREADGK SLVFLLWGNN AIKLVESLLG STSVGSGSKY PNIMVMKSVH
PSPLSASRGF FGTNHFKMIN DWLYNTRGEK MIDWSVVPGT SLREVQEANA RLESESKDP