Description:
Protein AF-9 homolog.
Molecular weight: 34667
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
15-DEC-2003, sequence version 1.
07-MAR-2006, entry version 15.
Phylogenetic order:
Eukaryota Fungi Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein AF9_NEUCR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AABX01000717 | EAA28594.1 | - |
| InterPro | IPR005033 | YEATS. | |
| Pfam | PF03366 | YEATS | 1. |
| PROSITE | PS51037 | YEATS | 1. |
Keywords:
Activator; Chromatin regulator; Coiled coil; DNA damage; DNA repair; Nuclear protein; Transcription; Transcription regulation.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=74-OR23-1A / FGSC 987;
RX MEDLINE=22598136; PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
Feature:
CHAIN 1 309 Protein AF-9 homolog.
/FTId=PRO_0000215930.
DOMAIN 15 129 YEATS.
COILED 265 309 Potential.
Comments:
-!- FUNCTION: Component of the SWR1 complex which mediates the ATP-
dependent exchange of histone H2A for the H2A variant HZT1 leading
to transcriptional regulation of selected genes by chromatin
remodeling. Component of the NuA4 histone acetyltransferase
complex which is involved in transcriptional activation of
selected genes principally by acetylation of nucleosomal histones
H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9
may also be required for viability in conditions in which the
structural integrity of the spindle is compromised (By
similarity).
-!- SUBUNIT: Component of the SWR1 chromatin remodeling complex and of
the NuA4 histone acetyltransferase complex (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasmic and nuclear (By similarity).
-!- DOMAIN: The coiled-coil domain is required for assembly into the
NuA4 complex (By similarity).
-!- SIMILARITY: Belongs to the YAF9 family.
-!- SIMILARITY: Contains 1 YEATS domain.
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Sequence length: 309
MAPPTGKRVK GVQIFRPFVY GTTARPFDEK TNPKPPGIPD DHTHSWTVFI KGIDDVDITY
WLRRVQFKLH ESIPNHVRMV EGVKGQPFQI HETGWGEFEI TMKLYYVPES SEKPQTLYHH
LRLHPFGRTE EEKEAMRLNG GEVISWVYEE QIFNEPYEPF YDILISGALP PSASTLKDGG
GGGGSGAATP TSANTPGASS SKGGNKKGHE RSHSRASVST NKDGKNNNES KEEPFVIQKS
EGGVLERSAM IPLVNRPGQP FSRETEQLEI QKLKEAKLKV DEMKKQMMEE LEKKQKRLEA
LRAESAKAP