Description:
DNA mismatch repair protein msh-2.
Molecular weight: 10506
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
07-FEB-2006, entry version 42.
Phylogenetic order:
Eukaryota Fungi Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MSH2_NEUCR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF030634 | AAB84225.1 | - |
| EMBL | AABX01000366 | EAA30407.1 | - |
| HSSP | P23909 | 1OH6 | |
| BioCyc | NCRA-XX3-01:NCRA-XX3-01-005978-MONOMER | -.1 | |
| InterPro | IPR011184 | MSH2. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| PIRSF | PIRSF005813 | MSH2 | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=74-OR23-1VA / FGSC 2489;
RA Huber D.H., Hausner G., Yamamoto K., Ishii C., Seidel-Rogol B.L.,
RA Bertrand H.;
RT "Neurospora crassa MSH2, a MutS homolog.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=74-OR23-1A / FGSC 987;
RX MEDLINE=22598136; PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
Feature:
CHAIN 1 937 DNA mismatch repair protein msh-2.
/FTId=PRO_0000115189.
NP_BIND 659 666 ATP (Potential).
Comments:
-!- FUNCTION: Involved in post-replicative DNA-mismatch repair. Binds
to mismatch-containing DNA (By similarity).
-!- SUBUNIT: Heterodimer of msh2 and msh6 (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 937
MSSRPELKVD DEHGFIRFYK SLPQLGEEAI RIFDRGDWYT AHGDDATFIA RTVYKTTSVI
RQLGRSDHTG LPSVTMTVTV FRQFLREALF KLGKRIEIWA SPSGRMNWKV VKQASPGNLQ
DVEDELGGQF EGAPVILAVK ISAKASEART VGVCFADASV RELGVSEFLD NDLYSNFEAL
LIQLGVKECI VTQDKGEKEK DPELAKLRQI IDNCGVAIAE RSAGEFGTKD IEQDLSRLLK
DERAASLLPQ TDLKLAMGSA SALIKYLGIL HDPSNFGQYQ LYQHDLAQFM KLDAAALKAL
NLMPGARDGA KNMSLYGLLN HCKTPVGSRL LSQWLKQPLM NAEEIEKRQQ LVEAFANDTE
LRQSMQEEHL RSIPDLYRLS KRFQRGKATL EDVVRAYQVV IRLPGFIGTL EGVMDEAYRD
PLDEVYTNKL RELSDSLVKL QEMVETTVDL DALDNHEFII KPEFDDSLRI IRKKLDRLRT
DMDNEFAEAA EDLGQEREKK IFLENHKVHG WCMRLTRTEA GCIRNNSRYL ECSTQKNGVY
FTTKTLQALR REFDQLSQNY NRTQSSLVNE VVGVAASYCP VLERLAAVLA HLDVIVSFAH
CSVHAPISYV RPKIHPRGTG RTVLTEARHP CMEVQDDVTF ITNDVTLTRE DSSFLIITGP
NMGGKSTYIR QIGVIALMAQ IGCFVPCSSA ELTIFDSILA RVGASDSQLK GVSTFMAEML
ETANILKSAT AESLIIIDEL GRGTSTYDGF GLAWAISEHI VKEIGCFALF ATHFHELTAL
ADQYPNVKNL HVTAHISGTD TDTDVITDED EKAKKKREVT LLYKVEPGIC DQSFGIHVAE
LVRFPDKVVR MAKRKADELE DFTSKHEEEN GGGLGVQYSK QDVEEGSALL KDVLVKWKDE
VKSGRMSKEE MVARLKELVQ KDERLLGNPF FKSVQAL