Description:
UV-damage endonuclease (EC 3.-.-.-) (UV-endonuclease UVE-1).
Molecular weight: 74413
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) base-excision repair( GO:0006284 ) nucleotide-excision repair (and GO:0045001, a synonym)( GO:0006289 )
Important dates:
06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 2.
07-FEB-2006, entry version 39.
Phylogenetic order:
Eukaryota Fungi Ascomycota Pezizomycotina Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UVE1_NEUCR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | D11392 | BAA74539.1 | - |
| EMBL | AL670004 | CAD21267.1 | - |
| EMBL | AABX01000279 | EAA31744.1 | - |
| BioCyc | NCRA-XX3-01:NCRA-XX3-01-000055-MONOMER | -.1 | |
| InterPro | IPR004601 | UvdE. | |
| Pfam | PF03851 | UvdE | 1. |
| TIGRFAMs | TIGR00629 | uvde | 1. |
Keywords:
DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=74-OR23-1A / FGSC 987;
RX MEDLINE=95292980; PubMed=7774597;
RA Yajima H., Takao M., Yasuhira S., Zhao J.H., Ishii C., Inoue H.,
RA Yasui A.;
RT "A eukaryotic gene encoding an endonuclease that specifically repairs
RT DNA damaged by ultraviolet light.";
RL EMBO J. 14:2393-2399(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=74-OR23-1A / FGSC 987;
RX MEDLINE=22542210; PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V.,
RA Hoheisel J.D., Fartmann B., Nyakatura G., Kempken F., Maier J.,
RA Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the
RT Neurospora genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=74-OR23-1A / FGSC 987;
RX MEDLINE=22598136; PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A.,
RA Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L.,
RA Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C.,
RA Marcotte E., Greenberg D., Roy A., Foley K., Naylor J.,
RA Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M.,
RA Mauceli E., Bielke C., Rudd S., Frishman D., Krystofova S.,
RA Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C.,
RA Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M.,
RA Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
Feature:
CHAIN 1 656 UV-damage endonuclease.
/FTId=PRO_0000215028.
Comments:
-!- FUNCTION: Endonuclease for the repair of UV-irradiated DNA.
Involved in the excision of cyclobutane pyrimidine dimers (CPD)
and 6-4 pyrimidine pyrimidones (6-4PP) which forms the UV damage
repair (UVDR) pathway.
-!- COFACTOR: Magnesium.
-!- SIMILARITY: Belongs to the uve1/uvsE family.
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Sequence length: 656
MPSRKSKAAA LDTPQSESST FSSTLDSSAP SPARNLRRSG RNILQPSSEK DRDHEKRSGE
ELAGRMMGKD ANGHCLREGK EQEEGVKMAI EGLARMERRL QRATKRQKKQ LEEDGIPVPS
VVSRFPTAPY HHKSTNAEER EAKEPVLKTH SKDVEREAEI GVDDVVKMEP AATNIIEPED
AQDAAERGAA RPPAVNSSYL PLPWKGRLGY ACLNTYLRNA KPPIFSSRTC RMASIVDHRH
PLQFEDEPEH HLKNKPDKSK EPQDELGHKF VQELGLANAR DIVKMLCWNE KYGIRFLRLS
SEMFPFASHP VHGYKLAPFA SEVLAEAGRV AAELGHRLTT HPGQFTQLGS PRKEVVESAI
RDLEYHDELL SLLKLPEQQN RDAVMIIHMG GQFGDKAATL ERFKRNYARL SQSCKNRLVL
ENDDVGWTVH DLLPVCEELN IPMVLDYHHH NICFDPAHLR EGTLDISDPK LQERIANTWK
RKGIKQKMHY SEPCDGAVTP RDRRKHRPRV MTLPPCPPDM DLMIEAKDKE QAVFELMRTF
KLPGFEKIND MVPYDRDDEN RPAPPVKAPK KKKGGKRKRT TDEEAAEPEE VDTAADDVKD
APEGPKEVPE EERAMGGPYN RVYWPLGCEE WLKPKKREVK KGKVPEEVED EGEFDG