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Description:
DNA mismatch repair protein mutS.
Molecular weight: 95568
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2004, sequence version 2.
07-MAR-2006, entry version 16.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Alcaligenaceae Bordetella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BORBR:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BX640442 | CAE32157.1 | ALT_INIT |
| GenomeReviews | BX470250_GR | BB1660.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RB50 / ATCC BAA-588;
RX MEDLINE=22827954; PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
RA Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
RA Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
RA Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
RA Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
RA Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
Feature:
CHAIN 1 876 DNA mismatch repair protein mutS.
/FTId=PRO_0000115072.
NP_BIND 626 633 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 876
MSQVIDSKHT PMMQQYLRLK AEAGPLLLFY RMGDFYEMFY EDAERAARLL NLTLTKRGNS
NGTPIPMAGI PVHAMEQYLA RLVALGESVA ICEQIGDPAA AKGPVERRIV RIVTPGTLTD
EALLPAKADR ALAAVCVTGK REPRAGLAWL NLASGAFHVT ECAPGQLESE LHRIAPAELI
QAESAELHMA FEGARTRVPD WHFEADGARA QLLAHFKTDS LGGFDVEDMP AAVCAAGALL
RYAARTQSQA LAHVQTIAAE RPGQYVLLDP VTRRNLELTQ TLSGEESPTL FSLLDGCRTP
MGSRLLRRWL HHPLRENEPV LARQHAIATM LTARQEGEQA FAAAALLETL RDALNAFPDI
ERIAARVALR SVRPRELASL RDALVALPAL HASLAPLSGS PRARELAAQL AMPPDIGELL
ARAVASEPAV AIRDGGVIAA GFDSELDELR ALATDGGDFL VQLEARERER TGIGNLRVEF
NRVHGFYIEV SKGQTDKVPE DYRRRQTLKN AERYITPELK TWEDRVLSAQ DRSLAREKWL
YEQLLDALAQ YVRPLSQCAS ALAELDTLAA LAEHARRHDW VAPELIDGAE IDIEAGRHPV
VERAIERFTP NGCRLDQTRR MLLITGPNMG GKSTYMRQVA LIALLARTGS FVPATRARVG
RLDRIFTRIG AADDLAGGRS TFMMEMTEAA AILAASTPAS LVLMDEIGRG TSTYDGLALA
WAIAYRLLTH NRALTLFATH YFELTRLPAE QPTAANVHLA AAESAGGIVF LHEVREGPAS
RSYGIQVAQR AGVPAAVIRQ ASRELERLEA QGAPTPQLGL FAAALDADVQ SQAMTEQAED
AAALAQLRDQ LAAIDPDSLT PREALDALYR LKQHLT