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Description:
DNA mismatch repair protein mutS.
Molecular weight: 96140
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2004, sequence version 2.
07-MAR-2006, entry version 16.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Alcaligenaceae Bordetella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_BORPA:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BX640429 | CAE37563.1 | ALT_INIT |
| GenomeReviews | BX470249_GR | BPP2265.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=12822 / ATCC BAA-587;
RX MEDLINE=22827954; PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
RA Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
RA Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
RA Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
RA Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
RA Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
Feature:
CHAIN 1 883 DNA mismatch repair protein mutS.
/FTId=PRO_0000115074.
NP_BIND 633 640 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 883
MSSTPKQTTG DALAGHTPMM QQYLRLKAEA GPLLLFYRMG DFYEMFYEDA ERAARLLNLT
LTKRGNSNGT PIPMAGIPVH AMEQYLARLV ALGESVAICE QIGDPAAAKG PVERRIVRIV
TPGTLTDEAL LPAKADRALA AVCVTGKREP RAGLAWLNLA SGAFHVTECA PGQLESELHR
IAPAELIQAE SAELHMAFEG ARTRVPDWHF EADGARAQLL AHFKTDSLGG FDVEDMPAAV
CAAGALLRYA ARTQSQALAH VQTIAAERPG QYVLLDPVTR RNLELTQTLS GEESPTLFSL
LDGCRTPMGS RLLRRWLHHP LRENEPVLAR QHAIATMLTV RQEGEQAFAA AGLLETLRDA
LNAFPDIERI AARVALRSVR PRELASLRDA LVALPALHAS LAPLSGSPRA RELAAQLAMP
PDIGELLARA VASEPAVAIR DGGVIAAGFD SELDELRALA TDGGDFLVQL EARERERTGI
GNLRVEFNRV HGFYIEVSKG QTDKVPEDYR RRQTLKNAER YITPELKTWE DRVLSAQDRS
LAREKWLYEQ LLDALAQYVR PLSQCASALA ELDTLAALAE HARRHDWVAP ELIDGAEIDI
EAGRHPVVER AIERFTPNGC RLDQTRRMLL ITGPNMGGKS TYMRQVALIA LLARTGSFVP
ATRARVGRLD RIFTRIGAAD DLAGGRSTFM MEMTEAAAIL AASTPASLVL MDEIGRGTST
YDGLALAWAI AYRLLTHNRA LTLFATHYFE LTRLPAEQPT AANVHLAAAE SAGGIVFLHE
VREGPASRSY GIQVAQRAGV PAAVIRQASR ELERLEAQGA PTPQLGLFAA ALDADVQSQA
MTEQAEDAAA LAQLRDQLAA IDPDSLTPRE ALDALYRLKQ HLT