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Description:
Protein recA (Recombinase A).
Molecular weight: 37949
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
07-MAR-2006, entry version 11.
Phylogenetic order:
Bacteria Proteobacteria Betaproteobacteria Burkholderiales Alcaligenaceae Bordetella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RECA_BORPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X53457 | CAA37537.1 | - |
| EMBL | BX640418 | CAE42821.1 | - |
| PIR | S10499 | S10499. | |
| HSSP | P03017 | 2REB | |
| SMR | P0A448 | 13-333.1 | |
| GenomeReviews | BX470248_GR | BP2546.1 | |
| HAMAP | MF_00268 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001553 | RecA_bac. | |
| Pfam | PF00154 | RecA | 1. |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR02012 | tigrfam_recA | 1. |
| PROSITE | PS00321 | RECA_1 | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleotide-binding; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=165;
RX MEDLINE=90332418; PubMed=2377463;
RA Favre D., Viret J.F.;
RT "Nucleotide sequence of the recA gene of Bordetella pertussis.";
RL Nucleic Acids Res. 18:4243-4243(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=165;
RX MEDLINE=91355297; PubMed=1832021; DOI=10.1016/0300-9084(91)90208-I;
RA Favre D., Cryz S.J. Jr., Viret J.F.;
RT "Cloning of the recA gene of Bordetella pertussis and characterization
RT of its product.";
RL Biochimie 73:235-244(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX MEDLINE=22827954; PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J.,
RA Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K.,
RA Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C.,
RA Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K.,
RA Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K.,
RA Unwin L., Whitehead S., Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
Feature:
CHAIN 1 353 Protein recA.
/FTId=PRO_0000122668.
NP_BIND 74 81 ATP (By similarity).
CONFLICT 66 68 RGR -> AA (in Ref. 1 and 2).
Comments:
-!- FUNCTION: Can catalyze the hydrolysis of ATP in the presence of
single-stranded DNA, the ATP-dependent uptake of single-stranded
DNA by duplex DNA, and the ATP-dependent hybridization of
homologous single-stranded DNAs. It interacts with lexA causing
its activation and leading to its autocatalytic cleavage.
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the recA family.
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Sequence length: 353
MDDKTSKAAA AEKAKALAAA LSQIEKQFGK GSIMRYGDNE VEHDIQVVST GSLGLDIALG
VGGLPRGRVI EVYGPESSGK TTLTLQVIAE MQKLGGTCAF VDAEHALDVQ YASKLGVNLT
DLLISQPDTG EQALEITDAL VRSGSVDLIV IDSVAALVPK AEIEGEMGDS LPGLQARLMS
QALRKLTATI KRTNCMVIFI NQIRMKIGVM FGNPETTTGG NALKFYSSVR LDIRRIGAIK
KGDEVVGNET RVKVVKNKVA PPFKQAEFDI MYGSGISREG EIIDLGVQAN VVDKSGAWYS
YSGNRIGQGK DNVREYLKEH KEMAIEIENK VRENQGIVSR AATFPASEAE DGE