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Description:
Probable ATP-dependent helicase dinG (EC 3.6.1.-) (DNA-damage-inducible protein G).
Molecular weight: 81440
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 3.
07-MAR-2006, entry version 48.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DING_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | L02123 | AAA53655.1 | - |
| EMBL | M81935 | AAA23685.1 | ALT_INIT |
| EMBL | U00096 | AAC73886.1 | - |
| EMBL | D90716 | BAA35459.1 | - |
| EMBL | D90717 | BAA35465.1 | - |
| PIR | G64816 | G64816. | |
| GenomeReviews | U00096_GR | b0799.1 | |
| EchoBASE | EB1332 | -.1 | |
| EcoGene | EG11357 | dinG. | |
| BioCyc | EcoCyc:EG11357-MONOMER | -.1 | |
| InterPro | IPR011545 | DEAD/DEAH_N. | |
| InterPro | IPR006554 | DEXDc2. | |
| InterPro | IPR006555 | Helic_c2. | |
| SMART | SM00487 | DEXDc | 1. |
| SMART | SM00491 | HELICc2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=94312114; PubMed=8037924;
RA Ohmori H.;
RT "Structural analysis of the rhlE gene of Escherichia coli.";
RL Jpn. J. Genet. 69:1-12(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=92332449; PubMed=1629168;
RA Lewis L.K., Mount D.W.;
RT "Interaction of LexA repressor with the asymmetric dinG operator and
RT complete nucleotide sequence of the gene.";
RL J. Bacteriol. 174:5110-5116(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [5]
RP SEQUENCE REVISION, AND PROBABLE FUNCTION.
RX MEDLINE=93219138; PubMed=8385320;
RA Koonin E.V.;
RT "Escherichia coli dinG gene encodes a putative DNA helicase related to
RT a group of eukaryotic helicases including Rad3 protein.";
RL Nucleic Acids Res. 21:1497-1497(1993).
Feature:
CHAIN 1 716 Probable ATP-dependent helicase dinG.
/FTId=PRO_0000101996.
NP_BIND 54 61 ATP (Probable).
MOTIF 248 251 DEGH box.
CONFLICT 513 513 N -> H (in Ref. 2).
Comments:
-!- FUNCTION: Probable helicase involved in DNA repair and perhaps
also replication.
-!- SIMILARITY: Belongs to the helicase family. DinG subfamily.
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Sequence length: 716
MALTAALKAQ IAAWYKALQE QIPDFIPRAP QRQMIADVAK TLAGEEGRHL AIEAPTGVGK
TLSYLIPGIA IAREEQKTLV VSTANVALQD QIYSKDLPLL KKIIPDLKFT AAFGRGRYVC
PRNLTALAST EPTQQDLLAF LDDELTPNNQ EEQKRCAKLK GDLDTYKWDG LRDHTDIAID
DDLWRRLSTD KASCLNRNCY YYRECPFFVA RREIQEAEVV VANHALVMAA MESEAVLPDP
KNLLLVLDEG HHLPDVARDA LEMSAEITAP WYRLQLDLFT KLVATCMEQF RPKTIPPLAI
PERLNAHCEE LYELIASLNN ILNLYMPAGQ EAEHRFAMGE LPDEVLEICQ RLAKLTEMLR
GLAELFLNDL SEKTGSHDIV RLHRLILQMN RALGMFEAQS KLWRLASLAQ SSGAPVTKWA
TREEREGQLH LWFHCVGIRV SDQLERLLWR SIPHIIVTSA TLRSLNSFSR LQEMSGLKEK
AGDRFVALDS PFNHCEQGKI VIPRMRVEPS IDNEEQHIAE MAAFFRKQVE SKKHLGMLVL
FASGRAMQRF LDYVTDLRLM LLVQGDQPRY RLVELHRKRV ANGERSVLVG LQSFAEGLDL
KGDLLSQVHI HKIAFPPIDS PVVITEGEWL KSLNRYPFEV QSLPSASFNL IQQVGRLIRS
HGCWGEVVIY DKRLLTKNYG KRLLDALPVF PIEQPEVPEG IVKKKEKTKS PRRRRR