|
|
|
|
|
|
Description:
DNA-damage-inducible protein I.
Molecular weight: 8949 M
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
08-NOV-2005, sequence version 1.
07-MAR-2006, entry version 5.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein DINI_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | D31709 | BAA06515.1 | - |
| EMBL | D90742 | BAA35858.1 | ALT_INIT |
| EMBL | D90743 | BAA35869.1 | ALT_INIT |
| EMBL | U00096 | AAC74145.1 | - |
| PIR | B64849 | B64849. | |
| PDB | 1GHH | NMR | A=1-81. |
| GenomeReviews | U00096_GR | b1061.1 | |
| EchoBASE | EB2536 | -.1 | |
| EcoGene | EG12670 | dinI. | |
| BioCyc | EcoCyc:G6558-MONOMER | -.1 | |
| InterPro | IPR010391 | DinI. | |
| Pfam | PF06183 | DinI | 1. |
Keywords:
3D-structure; Complete proteome; DNA damage; DNA repair; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=96272260; PubMed=8682790;
RA Yasuda T., Nagata T., Ohmori H.;
RT "Multicopy suppressors of the cold-sensitive phenotype of the pcsA68
RT (dinD68) mutation in Escherichia coli.";
RL J. Bacteriol. 178:3854-3859(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP CHARACTERIZATION.
RX MEDLINE=21142382; PubMed=11230150; DOI=10.1101/gad.862901;
RA Voloshin O.N., Ramirez B.E., Bax A., Camerini-Otero R.D.;
RT "A model for the abrogation of the SOS response by an SOS protein: a
RT negatively charged helix in DinI mimics DNA in its interaction with
RT RecA.";
RL Genes Dev. 15:415-427(2001).
RN [5]
RP STRUCTURE BY NMR.
RX MEDLINE=21025449; PubMed=11152126;
RA Ramirez B.E., Voloshin O.N., Camerini-Otero R.D., Bax A.;
RT "Solution structure of dinI provides insight into its mode of recA
RT inactivation.";
RL Protein Sci. 9:2161-2169(2000).
Feature:
CHAIN 1 81 DNA-damage-inducible protein I.
/FTId=PRO_0000201635.
STRAND 2 8
TURN 9 10
TURN 15 16
HELIX 17 32
STRAND 39 45
STRAND 49 53
HELIX 57 72
TURN 73 73
HELIX 74 77
Comments:
-!- FUNCTION: Involved in SOS regulation. Inhibits recA by preventing
recA to bind ssDNA. Can displace ssDNA from recA.
-!- SIMILARITY: Belongs to the dinI family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 81
MRIEVTIAKT SPLPAGAIDA LAGELSRRIQ YAFPDNEGHV SVRYAAANNL SVIGATKEDK
QRISEILQET WESADDWFVS E