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Description:
Exodeoxyribonuclease V gamma chain (EC 3.1.11.5) (ExodeoxyribonucleaseV 125 kDa polypeptide).
Molecular weight: 1288
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
01-APR-1988, sequence version 1.
07-MAR-2006, entry version 49.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EX5C_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X03966 | CAA27604.1 | - |
| EMBL | U29581 | AAB40469.1 | - |
| EMBL | U00096 | AAC75861.1 | - |
| EMBL | X06227 | CAA29575.1 | - |
| PIR | A24137 | NCECXV. | |
| PDB | 1W36 | X-ray | C/F=1-1122. |
| GenomeReviews | U00096_GR | b2822.1 | |
| EchoBASE | EB0818 | -.1 | |
| EcoGene | EG10825 | recC. | |
| BioCyc | EcoCyc:EG10825-MONOMER | -.1 | |
| GO | GO:0005515 | F:protein binding | IPI. |
| InterPro | IPR006697 | RecC. | |
| Pfam | PF04257 | Exonuc_V_gamma | 1. |
| TIGRFAMs | TIGR01450 | recC | 1. |
Keywords:
3D-structure; ATP-binding; Complete proteome; DNA damage; DNA repair; Endonuclease; Exonuclease; Helicase; Hydrolase; Nuclease; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=86232583; PubMed=3520484;
RA Finch P.W., Wilson R.E., Brown K., Hickson I.D., Tomkinson A.E.,
RA Emmerson P.T.;
RT "Complete nucleotide sequence of the Escherichia coli recC gene and of
RT the thyA-recC intergenic region.";
RL Nucleic Acids Res. 14:4437-4451(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1114-1122.
RX MEDLINE=87040734; PubMed=3534791;
RA Finch P.W., Wilson R.E., Brown K., Hickson I.D., Emmerson P.T.;
RT "Complete nucleotide sequence of the Escherichia coli ptr gene
RT encoding protease III.";
RL Nucleic Acids Res. 14:7695-7703(1986).
Feature:
CHAIN 1 1122 Exodeoxyribonuclease V gamma chain.
/FTId=PRO_0000087120.
STRAND 2 8
HELIX 10 22
STRAND 23 24
STRAND 29 30
STRAND 34 36
STRAND 38 39
HELIX 40 52
TURN 53 54
STRAND 55 55
STRAND 57 57
STRAND 61 61
HELIX 65 76
STRAND 77 79
STRAND 82 83
TURN 85 86
HELIX 88 102
STRAND 104 106
TURN 107 108
HELIX 109 114
TURN 115 116
STRAND 117 118
STRAND 120 121
HELIX 122 138
TURN 139 140
STRAND 141 142
HELIX 143 150
TURN 151 152
TURN 156 157
TURN 160 161
HELIX 162 178
TURN 179 180
STRAND 186 186
TURN 187 189
HELIX 190 198
STRAND 199 199
TURN 201 202
STRAND 206 206
STRAND 209 215
HELIX 221 230
TURN 231 233
STRAND 234 241
STRAND 243 243
STRAND 245 246
STRAND 249 249
HELIX 254 257
TURN 258 260
STRAND 261 261
STRAND 264 270
STRAND 272 272
STRAND 275 276
TURN 277 278
HELIX 279 282
STRAND 283 284
TURN 285 286
STRAND 288 291
STRAND 293 293
STRAND 296 296
HELIX 298 303
HELIX 305 314
TURN 315 316
STRAND 318 324
STRAND 331 331
STRAND 333 333
HELIX 334 344
TURN 345 345
STRAND 354 354
HELIX 355 359
TURN 362 363
STRAND 364 366
TURN 369 370
STRAND 373 381
HELIX 382 399
STRAND 400 400
TURN 401 402
HELIX 405 407
STRAND 408 413
HELIX 415 425
TURN 426 426
STRAND 427 427
STRAND 430 431
TURN 432 433
STRAND 438 439
STRAND 441 443
TURN 444 444
HELIX 445 447
HELIX 449 462
HELIX 467 473
TURN 474 475
STRAND 476 476
HELIX 477 482
TURN 483 484
HELIX 487 500
TURN 501 501
STRAND 504 504
STRAND 506 506
HELIX 508 513
TURN 514 515
STRAND 520 523
HELIX 524 535
STRAND 536 537
STRAND 539 539
TURN 540 541
STRAND 544 546
TURN 551 552
STRAND 553 553
STRAND 555 556
TURN 557 557
HELIX 558 577
TURN 578 578
STRAND 579 580
STRAND 582 582
HELIX 584 587
TURN 588 589
HELIX 590 598
STRAND 603 603
HELIX 604 625
TURN 626 626
STRAND 630 630
STRAND 632 632
HELIX 634 647
STRAND 649 650
TURN 652 655
STRAND 656 658
STRAND 660 662
TURN 666 667
STRAND 672 678
STRAND 681 681
TURN 682 684
STRAND 685 686
STRAND 693 694
HELIX 696 699
STRAND 700 700
TURN 703 704
HELIX 708 722
STRAND 723 732
STRAND 734 734
STRAND 736 738
STRAND 741 741
STRAND 744 744
HELIX 746 756
TURN 757 758
STRAND 759 760
STRAND 762 763
STRAND 765 767
HELIX 769 780
STRAND 783 783
STRAND 786 787
TURN 788 789
STRAND 790 790
HELIX 791 793
STRAND 794 797
TURN 798 799
STRAND 802 802
HELIX 804 810
TURN 811 812
STRAND 820 820
STRAND 830 830
STRAND 832 833
HELIX 834 840
STRAND 841 843
HELIX 844 850
TURN 851 853
STRAND 860 860
STRAND 866 867
STRAND 870 871
HELIX 874 889
TURN 890 891
HELIX 894 904
TURN 905 905
STRAND 907 907
STRAND 909 909
HELIX 910 932
TURN 933 934
STRAND 939 947
TURN 948 949
STRAND 950 959
STRAND 961 967
STRAND 969 970
HELIX 974 989
TURN 990 990
STRAND 991 991
STRAND 995 999
HELIX 1001 1003
STRAND 1005 1008
HELIX 1013 1029
TURN 1030 1032
STRAND 1033 1033
HELIX 1039 1049
STRAND 1050 1051
TURN 1052 1052
HELIX 1053 1055
STRAND 1056 1057
HELIX 1061 1075
STRAND 1076 1076
STRAND 1079 1081
TURN 1084 1085
STRAND 1087 1087
HELIX 1088 1091
TURN 1092 1093
STRAND 1095 1096
HELIX 1099 1117
TURN 1118 1119
Comments:
-!- FUNCTION: Exhibits a wide variety of catalytic activities
including ATP-dependent exonuclease, ATP-stimulated endonuclease,
ATP-dependent helicase and DNA-dependent ATPase activities.
-!- CATALYTIC ACTIVITY: Exonucleolytic cleavage (in the presence of
ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-
phosphooligonucleotides.
-!- SUBUNIT: Consist of three subunits; recB, recC and recD.
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Sequence length: 1122
MLRVYHSNRL DVLEALMEFI VERERLDDPF EPEMILVQST GMAQWLQMTL SQKFGIAANI
DFPLPASFIW DMFVRVLPEI PKESAFNKQS MSWKLMTLLP QLLEREDFTL LRHYLTDDSD
KRKLFQLSSK AADLFDQYLV YRPDWLAQWE TGHLVEGLGE AQAWQAPLWK ALVEYTHQLG
QPRWHRANLY QRFIETLESA TTCPPGLPSR VFICGISALP PVYLQALQAL GKHIEIHLLF
TNPCRYYWGD IKDPAYLAKL LTRQRRHSFE DRELPLFRDS ENAGQLFNSD GEQDVGNPLL
ASWGKLGRDY IYLLSDLESS QELDAFVDVT PDNLLHNIQS DILELENRAV AGVNIEEFSR
SDNKRPLDPL DSSITFHVCH SPQREVEVLH DRLLAMLEED PTLTPRDIIV MVADIDSYSP
FIQAVFGSAP ADRYLPYAIS DRRARQSHPV LEAFISLLSL PDSRFVSEDV LALLDVPVLA
ARFDITEEGL RYLRQWVNES GIRWGIDDDN VRELELPATG QHTWRFGLTR MLLGYAMESA
QGEWQSVLPY DESSGLIAEL VGHLASLLMQ LNIWRRGLAQ ERPLEEWLPV CRDMLNAFFL
PDAETEAAMT LIEQQWQAII AEGLGAQYGD AVPLSLLRDE LAQRLDQERI SQRFLAGPVN
ICTLMPMRSI PFKVVCLLGM NDGVYPRQLA PLGFDLMSQK PKRGDRSRRD DDRYLFLEAL
ISAQQKLYIS YIGRSIQDNS ERFPSVLVQE LIDYIGQSHY LPGDEALNCD ESEARVKAHL
TCLHTRMPFD PQNYQPGERQ SYAREWLPAA SQAGKAHSEF VQPLPFTLPE TVPLETLQRF
WAHPVRAFFQ MRLQVNFRTE DSEIPDTEPF ILEGLSRYQI NQQLLNALVE QDDAERLFRR
FRAAGDLPYG AFGEIFWETQ CQEMQQLADR VIACRQPGQS MEIDLACNGV QITGWLPQVQ
PDGLLRWRPS LLSVAQGMQL WLEHLVYCAS GGNGESRLFL RKDGEWRFPP LAAEQALHYL
SQLIEGYREG MSAPLLVLPE SGGAWLKTCY DAQNDAMLDD DSTLQKARTK FLQAYEGNMM
VRGEGDDIWY QRLWRQLTPE TMEAIVEQSQ RFLLPLFRFN QS