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Description:
Exodeoxyribonuclease X (EC 3.1.11.-) (Exonuclease X) (Exo X).
Molecular weight: 25133
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
20-DEC-2005, sequence version 1.
07-MAR-2006, entry version 4.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein EXOX_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AF194116 | AAF04847.1 | - |
| EMBL | U00096 | AAC74914.1 | - |
| PIR | D64946 | D64946. | |
| GenomeReviews | U00096_GR | b1844.1 | |
| EchoBASE | EB3785 | -.1 | |
| EcoGene | EG14031 | exoX. | |
| BioCyc | EcoCyc:G7016-MONOMER | -.1 |
Keywords:
Complete proteome; DNA damage; DNA repair; Exonuclease; Hydrolase; Magnesium; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RX MEDLINE=99445570; PubMed=10514496; DOI=10.1074/jbc.274.42.30094;
RA Viswanathan M., Lovett S.T.;
RT "Exonuclease X of Escherichia coli. A novel 3'-5' DNase and DnaQ
RT superfamily member involved in DNA repair.";
RL J. Biol. Chem. 274:30094-30100(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
Feature:
CHAIN 1 220 Exodeoxyribonuclease X.
/FTId=PRO_0000087136.
Comments:
-!- FUNCTION: Capable of degrading both single-strand and double-
strand DNA with 3' to 5' polarity. Has higher affinity for ssDNA
ends than for dsDNA. May facilitate recombinational repair by pre-
synaptic and/or post-synaptic DNA degradation.
-!- COFACTOR: Magnesium.
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Sequence length: 220
MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI HRITEAMVAD
KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM KLARRLWPGI KYSNMALYKT
RKLNVQTPPG LHHHRALYDC YITAALLIDI MNTSGWTAEQ MADITGRPSL MTTFTFGKYR
GKAVSDVAER DPGYLRWLFN NLDSMSPELR LTLKHYLENT