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Description:
Putative molybdenum transport ATP-binding protein modF (Photorepairprotein phrA).
Molecular weight: 54536
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 2.
07-MAR-2006, entry version 49.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MODF_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U07867 | AAB06891.1 | - |
| EMBL | U27192 | AAB60176.1 | - |
| EMBL | U00096 | AAC73847.1 | - |
| EMBL | D90714 | BAA35422.1 | - |
| EMBL | D90715 | BAA35424.1 | - |
| EMBL | X69182 | CAA48926.1 | - |
| PIR | JC6038 | JC6038. | |
| GenomeReviews | U00096_GR | b0760.1 | |
| EchoBASE | EB1628 | -.1 | |
| EcoGene | EG11677 | modF. | |
| BioCyc | EcoCyc:MODF-MONOMER | -.1 | |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR003439 | ABC_transp_like. | |
| Pfam | PF00005 | ABC_tran | 2. |
| ProDom | PD000006 | ABC_transporter | 2. |
| SMART | SM00382 | AAA | 2. |
| PROSITE | PS00211 | ABC_TRANSPORTER_1 | FALSE_NEG. |
| PROSITE | PS50893 | ABC_TRANSPORTER_2 | 2. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; Inner membrane; Membrane; Molybdenum; Nucleotide-binding; Repeat; Transport.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12 / MC1000;
RX MEDLINE=96151473; PubMed=8564363;
RA Walkenhorst H.M., Hemschemeier S.K., Eichenlaub R.;
RT "Molecular analysis of the molybdate uptake operon, modABCD, of
RT Escherichia coli and modR, a regulatory gene.";
RL Microbiol. Res. 150:347-361(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=96146523; PubMed=8550508;
RA Grunden A.M., Ray R.M., Rosentel J.K., Healy F.G., Shanmugam K.T.;
RT "Repression of the Escherichia coli modABCD (molybdate transport)
RT operon by ModE.";
RL J. Bacteriol. 178:735-744(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 151-490.
RC STRAIN=K12 / C600;
RX MEDLINE=94143420; PubMed=8310005;
RA Dorrell N., Ahmed A.H., Moss S.H.;
RT "Photoreactivation in a phrB mutant of Escherichia coli K-12: evidence
RT for the role of a second protein in photorepair.";
RL Photochem. Photobiol. 58:831-835(1993).
Feature:
CHAIN 1 490 Putative molybdenum transport ATP-binding
protein modF.
/FTId=PRO_0000092566.
DOMAIN 4 235 ABC transporter 1.
DOMAIN 261 489 ABC transporter 2.
NP_BIND 36 43 ATP 1 (Potential).
NP_BIND 293 300 ATP 2 (Potential).
CONFLICT 320 320 L -> A (in Ref. 5).
CONFLICT 322 322 G -> R (in Ref. 5).
CONFLICT 325 325 R -> A (in Ref. 5).
Comments:
-!- FUNCTION: Involved in the transport of molybdenum into the cell.
Involved in photorepair. Could act on UV-induced DNA damage other
than pyrimidine dimers.
-!- SUBCELLULAR LOCATION: Bacterial cell inner membrane; peripheral
membrane protein (By similarity).
-!- SIMILARITY: Belongs to the ABC transporter family.
-!- SIMILARITY: Contains 2 ABC transporter domains.
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Sequence length: 490
MSSLQILQGT FRLSDTKTLQ LPQLTLNAGD SWAFVGSNGS GKSALARALA GELPLLKGER
QSQFSHITRL SFEQLQKLVS DEWQRNNTDM LGPGEDDTGR TTAEIIQDEV KDAPRCMQLA
QQFGITALLD RRFKYLSTGE TRKTLLCQAL MSEPDLLILD EPFDGLDVAS RQQLAERLAS
LHQSGITLVL VLNRFDEIPE FVQFAGVLAD CTLAETGAKE ELLQQALVAQ LAHSEQLEGV
QLPEPDEPSA RHALPANEPR IVLNNGVVSY NDRPILNNLS WQVNPGEHWQ IVGPNGAGKS
TLLSLVTGDH PQGYSNDLTL FGRRRGSGET IWDIKKHIGY VSSSLHLDYR VSTTVRNVIL
SGYFDSIGIY QAVSDRQQKL VQQWLDILGI DKRTADAPFH SLSWGQQRLA LIVRALVKHP
TLLILDEPLQ GLDPLNRQLI RRFVDVLISE GETQLLFVSH HAEDAPACIT HRLEFVPDGG
LYRYVLTKIY