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Description:
Protein mucA (EC 3.4.21.-) [Contains: Protein mucA'].
Molecular weight: 16527
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-APR-1988, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
21-FEB-2006, entry version 10.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUCA_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | D90147 | BAA14175.1 | - |
| EMBL | M13388 | AAA98277.1 | - |
| PIR | D23157 | ZWECAP. | |
| HSSP | P04153 | 1I4V | |
| MEROPS | S24.003 | -. | |
| InterPro | IPR006198 | Pept_S24_S26. | |
| InterPro | IPR006197 | Pept_S24_SOS. | |
| Pfam | PF00717 | Peptidase_S24 | 1. |
| PRINTS | PR00726 | LEXASERPTASE. |
Keywords:
Autocatalytic cleavage; DNA damage; DNA repair; Hydrolase; Plasmid; Protease; Serine protease; SOS mutagenesis; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Tanooka H.;
RL Submitted (MAY-1990) to the PIR data bank.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=85242678; PubMed=2989816;
RA Perry K.L., Elledge S.J., Mitchell B.B., Marsh L., Walker G.C.;
RT "umuDC and mucAB operons whose products are required for UV light- and
RT chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share
RT homology.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:4331-4335(1985).
Feature:
CHAIN 1 146 Protein mucA.
/FTId=PRO_0000041985.
CHAIN 27 146 Protein mucA'.
/FTId=PRO_0000027299.
ACT_SITE 62 62 Involved in auto-cleavage (By
similarity).
ACT_SITE 99 99 Involved in auto-cleavage (By
similarity).
SITE 26 27 Cleavage (auto-).
CONFLICT 13 13 Missing (in Ref. 2).
Comments:
-!- FUNCTION: Involved in UV protection and mutation.
-!- MISCELLANEOUS: The mucAB operon is the plasmid-borne analog of the
E.coli umuDC operon.
-!- SIMILARITY: Belongs to the peptidase S24 family.
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Sequence length: 146
MKVDIFESSG ASRVHSIPFY LQRISAGFPS PAQGYEKQEL NLHEYCVRHP SATYFLRVSG
SSMEDGRIHD GDVLVVDRSL TASHGSIVVA CIHNEFTVKR LLLRPRPCLM PMNKDFPVYY
IDPDNESVEI WGVVTHSLIE HPVCLR