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Description:
DNA mismatch repair protein mutS.
Molecular weight: 95247
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
01-MAR-1992, sequence version 1.
07-MAR-2006, entry version 57.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_ECOLI:
Keywords:
3D-structure; ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=92041649; PubMed=1938937;
RA Schlensog V., Boeck A.;
RT "The Escherichia coli fdv gene probably encodes mutS and is located at
RT minute 58.8 adjacent to the hyc-hyp gene cluster.";
RL J. Bacteriol. 173:7414-7415(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 602-731.
RC STRAIN=Various strains;
RA Denamur E.;
RL Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
Feature:
CHAIN 1 853 DNA mismatch repair protein mutS.
/FTId=PRO_0000115094.
NP_BIND 614 621 ATP (Potential).
HELIX 7 9
STRAND 10 10
HELIX 12 22
TURN 23 23
STRAND 24 24
TURN 25 26
STRAND 27 33
TURN 34 35
STRAND 36 40
HELIX 41 51
TURN 52 52
STRAND 56 58
TURN 61 62
STRAND 63 64
STRAND 66 72
HELIX 73 85
TURN 86 87
STRAND 90 95
STRAND 97 97
HELIX 99 101
STRAND 103 105
STRAND 108 114
TURN 116 118
TURN 122 124
STRAND 125 125
TURN 127 128
STRAND 129 129
STRAND 133 138
STRAND 140 141
STRAND 143 148
TURN 150 152
STRAND 155 158
STRAND 161 162
HELIX 163 173
STRAND 176 181
TURN 182 183
STRAND 185 185
HELIX 187 189
TURN 190 192
TURN 194 195
STRAND 196 199
HELIX 201 204
HELIX 206 217
TURN 218 218
STRAND 220 220
STRAND 222 222
HELIX 223 225
TURN 226 226
TURN 228 229
HELIX 231 248
STRAND 250 250
TURN 253 254
STRAND 259 260
HELIX 263 265
STRAND 266 266
STRAND 268 269
HELIX 271 277
TURN 278 278
STRAND 279 281
TURN 283 284
STRAND 285 285
STRAND 287 287
TURN 288 289
STRAND 290 290
HELIX 291 295
STRAND 299 300
HELIX 301 312
STRAND 313 313
STRAND 315 315
HELIX 318 331
TURN 332 334
HELIX 335 343
TURN 344 345
HELIX 348 356
TURN 357 358
HELIX 362 372
TURN 373 374
HELIX 375 383
STRAND 384 384
HELIX 388 396
TURN 397 397
HELIX 401 410
STRAND 411 411
STRAND 413 414
STRAND 417 417
STRAND 419 419
TURN 420 421
STRAND 425 425
TURN 427 428
STRAND 429 429
HELIX 431 440
TURN 441 441
HELIX 443 458
TURN 459 459
TURN 461 462
STRAND 464 468
TURN 469 471
STRAND 472 478
HELIX 479 482
TURN 483 484
STRAND 485 485
TURN 487 488
STRAND 490 494
STRAND 496 502
HELIX 504 564
TURN 565 566
STRAND 568 568
STRAND 571 572
STRAND 574 576
STRAND 578 583
TURN 586 590
STRAND 591 591
STRAND 593 594
STRAND 599 603
STRAND 605 607
STRAND 609 613
TURN 616 617
STRAND 618 619
HELIX 620 634
TURN 635 637
STRAND 640 647
STRAND 652 657
HELIX 671 683
TURN 686 687
STRAND 689 694
STRAND 699 700
TURN 701 702
HELIX 703 717
TURN 718 719
STRAND 722 726
STRAND 728 728
HELIX 730 738
STRAND 739 739
TURN 740 741
STRAND 742 751
STRAND 753 754
STRAND 756 765
STRAND 768 769
HELIX 772 778
TURN 779 780
HELIX 783 796
TURN 797 798
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity.
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 853
MSAIENFDAH TPMMQQYLRL KAQHPEILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA
SAGEPIPMAG IPYHAVENYL AKLVNQGESV AICEQIGDPA TSKGPVERKV VRIVTPGTIS
DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY
AEDFAEMSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL
LQYAKDTQRT TLPHIRSITM EREQDSIIMD AATRRNLEIT QNLAGGAENT LASVLDCTVT
PMGSRMLKRW LHMPVRDTRV LLERQQTIGA LQDFTAGLQP VLRQVGDLER ILARLALRTA
RPRDLARMRH AFQQLPELRA QLETVDSAPV QALREKMGEF AELRDLLERA IIDTPPVLVR
DGGVIASGYN EELDEWRALA DGATDYLERL EVRERERTGL DTLKVGFNAV HGYYIQISRG
QSHLAPINYM RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYEE LFDLLLPHLE
ALQQSASALA ELDVLVNLAE RAYTLNYTCP TFIDKPGIRI TEGRHPVVEQ VLNEPFIANP
LNLSPQRRML IITGPNMGGK STYMRQTALI ALMAYIGSYV PAQKVEIGPI DRIFTRVGAA
DDLASGRSTF MVEMTETANI LHNATEYSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK
ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG
VPKEVIKRAR QKLRELESIS PNAAATQVDG TQMSLLSVPE ETSPAVEALE NLDPDSLTPR
QALEWIYRLK SLV