|
|
|
|
|
|
Description:
dATP pyrophosphohydrolase (EC 3.6.1.-).
Molecular weight: 17306
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
20-DEC-2005, sequence version 1.
07-MAR-2006, entry version 4.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein NUDB_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | X59551 | CAA42124.1 | - |
| EMBL | D10165 | BAA01029.1 | - |
| EMBL | D90829 | BAA15676.1 | - |
| EMBL | U00096 | AAC74935.1 | - |
| PIR | B38113 | B38113. | |
| HSSP | Q9U2M7 | 1KT9 | |
| GenomeReviews | U00096_GR | b1865.1 | |
| EchoBASE | EB1128 | -.1 | |
| EcoGene | EG11138 | nudB. | |
| BioCyc | EcoCyc:EG11138-MONOMER | -.1 | |
| GO | GO:0005515 | F:protein binding | IPI. |
| PROSITE | PS00893 | NUDIX | 1. |
Keywords:
Complete proteome; Hydrolase.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=92041688; PubMed=1657895;
RA Sharples G.J., Lloyd R.G.;
RT "Resolution of Holliday junctions in Escherichia coli: identification
RT of the ruvC gene product as a 19-kilodalton protein.";
RL J. Bacteriol. 173:7711-7715(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=91358366; PubMed=1885548;
RA Takahagi M., Iwasaki H., Nakata A., Shinagawa H.;
RT "Molecular analysis of the Escherichia coli ruvC gene, which encodes a
RT Holliday junction-specific endonuclease.";
RL J. Bacteriol. 173:5747-5753(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=97251358; PubMed=9097040; DOI=10.1093/dnares/3.6.379;
RA Itoh T., Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K.,
RA Kasai H., Kimura S., Kitakawa M., Kitagawa M., Makino K., Miki T.,
RA Mizobuchi K., Mori H., Mori T., Motomura K., Nakade S., Nakamura Y.,
RA Nashimoto H., Nishio Y., Oshima T., Saito N., Sampei G., Seki Y.,
RA Sivasundaram S., Tagami H., Takeda J., Takemoto K., Wada C.,
RA Yamamoto Y., Horiuchi T.;
RT "A 460-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 40.1-50.0 min region on the linkage map.";
RL DNA Res. 3:379-392(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [5]
RP CHARACTERIZATION.
RX MEDLINE=94216358; PubMed=8163538;
RA Bullions L.C., Mejean V., Claverys J.-P., Bessman M.J.;
RT "Purification of the MutX protein of Streptococcus pneumoniae, a
RT homologue of Escherichia coli MutT. Identification of a novel
RT catalytic domain for nucleoside triphosphate pyrophosphohydrolase
RT activity.";
RL J. Biol. Chem. 269:12339-12344(1994).
Feature:
CHAIN 1 150 dATP pyrophosphohydrolase.
/FTId=PRO_0000056952.
MOTIF 41 62 Nudix box.
Comments:
-!- FUNCTION: Hydrolysis of nucleoside triphosphates with a preference
for dATP.
-!- SIMILARITY: Belongs to the Nudix hydrolase family.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
Sequence length: 150
MKDKVYKRPV SILVVIYAQD TKRVLMLQRR DDPDFWQSVT GSVEEGETAP QAAMREVKEE
VTIDVVAEQL TLIDCQRTVE FEIFSHLRHR YAPGVTRNTE SWFCLALPHE RQIVFTEHLA
YKWLDAPAAA ALTKSWSNRQ AIEQFVINAA