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Description:
Putative Holliday junction resolvase (EC 3.1.-.-).
Molecular weight: 15186
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
07-JUN-2005, sequence version 1.
07-MAR-2006, entry version 6.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RUVX_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | U28377 | AAA69116.1 | ALT_INIT |
| EMBL | U00096 | AAC75986.1 | - |
| PIR | D65080 | D65080. | |
| PDB | 1NMN | X-ray | A/B=1-138. |
| PDB | 1NU0 | X-ray | A/B=1-138. |
| PDB | 1OVQ | NMR | A=1-138. |
| GenomeReviews | U00096_GR | b2949.1 | |
| EchoBASE | EB3075 | -.1 | |
| EcoGene | EG13290 | yqgF. | |
| HAMAP | MF_00651 | - | 1. |
| InterPro | IPR005227 | HJR_YqgF. | |
| InterPro | IPR012337 | RNaseH_fold. | |
| InterPro | IPR006641 | YqgFc. | |
| Pfam | PF03652 | UPF0081 | 1. |
| SMART | SM00732 | YqgFc | 1. |
| TIGRFAMs | TIGR00250 | HJR_YqgF | 1. |
Keywords:
3D-structure; Complete proteome; DNA damage; DNA recombination; DNA repair; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [2]
RP STRUCTURE BY NMR.
RX MEDLINE=22147548; PubMed=12153044; DOI=10.1023/A:1016368102539;
RA Liu D., Repaka P., Taremi S.S., Wyss D.F.;
RT "Backbone 1H, 15N and 13C resonance assignments of YqgF, an
RT Escherichia coli protein of unknown structure and function.";
RL J. Biomol. NMR 23:159-160(2002).
Feature:
CHAIN 1 138 Putative Holliday junction resolvase.
/FTId=PRO_0000172058.
STRAND 4 9
STRAND 12 21
TURN 22 25
STRAND 26 36
TURN 37 38
STRAND 39 40
HELIX 42 52
STRAND 55 63
TURN 65 66
STRAND 67 67
STRAND 69 69
HELIX 71 87
STRAND 91 97
HELIX 118 121
TURN 122 123
HELIX 124 135
TURN 136 137
Comments:
-!- FUNCTION: Could be a nuclease that resolves Holliday junction
intermediates in genetic recombination.
-!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
-!- SIMILARITY: Belongs to the yqgF HJR family.
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Sequence length: 138
MSGTLLAFDF GTKSIGVAVG QRITGTARPL PAIKAQDGTP DWNIIERLLK EWQPDEIIVG
LPLNMDGTEQ PLTARARKFA NRIHGRFGVE VKLHDERLST VEARSGLFEQ GGYRALNKGK
VDSASAVIIL ESYFEQGY