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Description:
Cell division inhibitor.
Molecular weight: 18801
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
20-DEC-2005, sequence version 1.
07-MAR-2006, entry version 4.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein SULA_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | V00307 | CAA23587.1 | ALT_FRAME |
| EMBL | V00358 | CAA23654.1 | - |
| EMBL | D90733 | BAA35716.1 | - |
| EMBL | D90734 | BAA35723.1 | - |
| EMBL | U00096 | AAC74044.1 | - |
| PIR | A29016 | QQECA1. | |
| GenomeReviews | U00096_GR | b0958.1 | |
| EchoBASE | EB0977 | -.1 | |
| EcoGene | EG10984 | sulA. | |
| BioCyc | EcoCyc:EG10984-MONOMER | -.1 |
Keywords:
Cell cycle; Cell division; Complete proteome; DNA damage; DNA repair; Inner membrane; Membrane; Septation; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=87248093; PubMed=3297925; DOI=10.1016/0378-1119(87)90392-1;
RA Freudl R., Braun G., Honore N., Cole S.T.;
RT "Evolution of the enterobacterial sulA gene: a component of the SOS
RT system encoding an inhibitor of cell division.";
RL Gene 52:31-40(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX MEDLINE=81053729; PubMed=6253901;
RA Beck E., Bremer E.;
RT "Nucleotide sequence of the gene ompA coding the outer membrane
RT protein II of Escherichia coli K-12.";
RL Nucleic Acids Res. 8:3011-3024(1980).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
RX MEDLINE=83244178; PubMed=6306396; DOI=10.1007/BF00325901;
RA Cole S.T.;
RT "Characterisation of the promoter for the LexA regulated sulA gene of
RT Escherichia coli.";
RL Mol. Gen. Genet. 189:400-404(1983).
Feature:
CHAIN 1 169 Cell division inhibitor.
/FTId=PRO_0000072305.
REGION 31 149 Conserved region.
REGION 160 169 Lon protein binding site (Probable).
Comments:
-!- FUNCTION: SulA is a component of the SOS system and an inhibitor
of cell division. Accumulation of sulA causes rapid cessation of
cell division and the appearance of long, non-septate filaments.
The expression of sulA is repressed by the lexA protein. FtsZ
seems to be the target of sulA.
-!- SUBCELLULAR LOCATION: Bacterial cell inner membrane; peripheral
membrane protein.
-!- MISCELLANEOUS: The N-terminus of the sulA protein might be
involved in recognizing the cell division apparatus.
-!- SIMILARITY: Belongs to the sulA family.
-!- CAUTION: Ref.2 sequence differs from that shown due to a
frameshift in position 145.
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Sequence length: 169
MYTSGYAHRS SSFSSAASKI ARVSTENTTA GLISEVVYRE DQPMMTQLLL LPLLQQLGQQ
SRWQLWLTPQ QKLSREWVQA SGLPLTKVMQ ISQLSPCHTV ESMVRALRTG NYSVVIGWLA
DDLTEEEHAE LVDAANEGNA MGFIMRPVSA SSHATRQLSG LKIHSNLYH