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Description:
Protein umuC.
Molecular weight: 47680
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
07-MAR-2006, entry version 53.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein UMUC_ECOLI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | M10107 | AAA24729.1 | - |
| EMBL | M13387 | AAA98074.1 | - |
| EMBL | U00096 | AAC74268.1 | - |
| EMBL | D90752 | BAA36031.1 | - |
| EMBL | D90753 | BAA36039.1 | - |
| PIR | E64864 | ZWECC. | |
| HSSP | P96022 | 1IM4 | |
| GenomeReviews | U00096_GR | b1184.1 | |
| EchoBASE | EB1049 | -.1 | |
| EcoGene | EG11056 | umuC. | |
| BioCyc | EcoCyc:EG11056-MONOMER | -.1 | |
| HAMAP | MF_01113 | atypical | 1. |
| InterPro | IPR001126 | UMUC_like. | |
| Pfam | PF00817 | IMS | 1. |
| PROSITE | PS50173 | UMUC | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; SOS mutagenesis; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=85242679; PubMed=2989817;
RA Kitagawa Y., Akaboshi E., Shinagawa H., Horii T., Ogawa H., Kato T.;
RT "Structural analysis of the umu operon required for inducible
RT mutagenesis in Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:4336-4340(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX MEDLINE=85242678; PubMed=2989816;
RA Perry K.L., Elledge S.J., Mitchell B.B., Marsh L., Walker G.C.;
RT "umuDC and mucAB operons whose products are required for UV light- and
RT chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share
RT homology.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:4331-4335(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655;
RX MEDLINE=97426617; PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
RA Mau B., Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1474(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110;
RX MEDLINE=97061202; PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
RA Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
RA Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
RA Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
RA Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
RA Yano M., Horiuchi T.;
RT "A 718-kb DNA sequence of the Escherichia coli K-12 genome
RT corresponding to the 12.7-28.0 min region on the linkage map.";
RL DNA Res. 3:137-155(1996).
RN [5]
RP MUTAGENESIS.
RX MEDLINE=92318898; PubMed=1320188; DOI=10.1007/BF00265442;
RA Koch W.H., Ennis D.G., Levine A.S., Woodgate R.;
RT "Escherichia coli umuDC mutants: DNA sequence alterations and UmuD
RT cleavage.";
RL Mol. Gen. Genet. 233:443-448(1992).
Feature:
CHAIN 1 422 Protein umuC.
/FTId=PRO_0000173982.
DOMAIN 2 188 UmuC.
MUTAGEN 75 75 E->K: In umuC36; non-mutable.
MUTAGEN 101 101 D->N: In umuC104; non-mutable.
MUTAGEN 290 290 T->K: In umuC25; non-mutable.
CONFLICT 152 152 A -> E (in Ref. 1).
Comments:
-!- FUNCTION: Involved in UV protection and mutation. Essential for
induced (or SOS) mutagenesis. May modify the DNA replication
machinery to allow bypass synthesis across a damaged template.
-!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
-!- SIMILARITY: Contains 1 umuC domain.
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Sequence length: 422
MFALCDVNAF YASCETVFRP DLWGKPVVVL SNNDGCVIAR NAEAKALGVK MGDPWFKQKD
LFRRCGVVCF SSNYELYADM SNRVMSTLEE LSPRVEIYSI DEAFCDLTGV RNCRDLTDFG
REIRATVLQR THLTVGVGIA QTKTLAKLAN HAAKKWQRQT GGVVDLSNLE RQRKLMSALP
VDDVWGIGRR ISKKLDAMGI KTVLDLADTD IRFIRKHFNV VLERTVRELR GEPCLQLEEF
APTKQEIICS RSFGERITDY PSMRQAICSY AARAAEKLRS EHQYCRFIST FIKTSPFALN
EPYYGNSASV KLLTPTQDSR DIINAATRSL DAIWQAGHRY QKAGVMLGDF FSQGVAQLNL
FDDNAPRPGS EQLMTVMDTL NAKEGRGTLY FAGQGIQQQW QMKRAMLSPR YTTRSSDLLR
VK