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Description:
Flap structure-specific endonuclease (EC 3.1.-.-).
Molecular weight: 40153
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
12-FEB-2003, sequence version 2.
07-MAR-2006, entry version 29.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Desulfurococcales Desulfurococcaceae Aeropyrum.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein FEN_AERPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000002 | BAA79026.1 | ALT_INIT |
| HSSP | O93634 | 1B43 | |
| GenomeReviews | BA000002_GR | APE0115.1 | |
| BioCyc | APER56636:APE0115-MONOMER | -.1 | |
| HAMAP | MF_00614 | - | 1. |
| InterPro | IPR000513 | Exo_N_I. | |
| InterPro | IPR008918 | HhH2. | |
| InterPro | IPR006086 | XPG_I. | |
| InterPro | IPR006085 | XPG_N. | |
| InterPro | IPR006084 | XPGC_Rad. | |
| Pfam | PF00867 | XPG_I | 1. |
| Pfam | PF00752 | XPG_N | 1. |
| PRINTS | PR00853 | XPGRADSUPER. | |
| SMART | SM00279 | HhH2 | 1. |
| SMART | SM00484 | XPGI | 1. |
| SMART | SM00485 | XPGN | 1. |
| PROSITE | PS00841 | XPG_1 | 1. |
Keywords:
Complete proteome; Endonuclease; Hydrolase; Magnesium; Metal-binding; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K1;
RX MEDLINE=99310339; PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic
RT crenarchaeon, Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
Feature:
CHAIN 1 351 Flap structure-specific endonuclease.
/FTId=PRO_0000154049.
METAL 158 158 Magnesium 1 (By similarity).
Comments:
-!- FUNCTION: Endonuclease that cleave the 5'overhanging flap
structure that is generated by displacement synthesis when DNA
polymerase encounters the 5'end of a downstream Okazaki fragment.
Has 5'endo-/exonuclease and 5'pseudo-Y-endonuclease activities.
Cleaves the junction between single and double-stranded regions of
flap DNA (By similarity).
-!- COFACTOR: Binds 2 magnesium ions per subunit (By similarity).
-!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family. FEN1
subfamily.
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Sequence length: 351
MLGVNLRELI PPEARREVEL RALSGYVLAL DAYNMLYQFL TAIRQPDGTP LLDREGRVTS
HLSGLFYRTI NLVEEGIKPV YVFDGKPPEM KSREVEERLR RKAEAEARYR RAVEAGEVEE
ARKYAMMAAR LTSDMVEESK ELLDAMGMPW VQAPAEGEAQ AAYMARKGDA WATGSQDYDS
LLFGSPRLVR NLAITGRRKL PGRDQYVEIK PEIIELEPLL SKLGITREQL IAVGILLGTD
YNPGGVRGYG PKTALRLVKS LGDPMKVLAS VPRGEYDPDY LRKVYEYFLN PPVTDDYKIE
FRKPDQDKVR EILVERHDFN PERVERALER LGKAYREKLR GRQSRLDMWF G