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Description:
Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease)(Deoxyribonuclease V) (DNase V).
Molecular weight: 27258
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
07-DEC-2004, sequence version 2.
07-MAR-2006, entry version 23.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Desulfurococcales Desulfurococcaceae Aeropyrum.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein NFI_AERPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | BA000002 | BAA79471.1 | ALT_INIT |
| PIR | C72747 | C72747. | |
| GenomeReviews | BA000002_GR | APE0506.1 | |
| BioCyc | APER56636:APE0506-MONOMER | -.1 | |
| HAMAP | MF_00801 | - | 1. |
| InterPro | IPR007581 | Endonuc_V. | |
| Pfam | PF04493 | Endonuclease_5 | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Magnesium; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K1;
RX MEDLINE=99310339; PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic
RT crenarchaeon, Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
Feature:
CHAIN 1 255 Endonuclease V.
/FTId=PRO_0000159683.
Comments:
-!- FUNCTION: Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA. Acts in DNA repair (By similarity).
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
-!- COFACTOR: Magnesium (By similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the endonuclease V family.
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Sequence length: 255
MNRREVRCAF SASKAARAQL LLRGKVRLEP LPTRPRTVLG LDASYSAKDG VGVGAAVLIS
LETLEPVDCR VYISRVCIPY IPGLLAFREL AVMAPAAAAL SAEADVVMVD GHGIAHPRRF
GIASHVGVIL ERPSIGVAKK KLVGTLVEGP GGMYVVQDGE RLAIVLGTRP REVYVSPGHR
ITLEEAASIA RATIRPGGWM PEPTRLADVI SKALKTIIGG QSLINSALAS LCRVKLGPRL
EELERPLRRA GLEVE