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Description:
DNA repair and recombination protein radA.
Molecular weight: 35320
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
27-APR-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
07-MAR-2006, entry version 39.
Phylogenetic order:
Archaea Crenarchaeota Thermoprotei Desulfurococcales Desulfurococcaceae Aeropyrum.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein RADA_AERPE:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AB077994 | BAB83900.1 | - |
| EMBL | AB077995 | BAB83901.1 | - |
| EMBL | AB077996 | BAB83902.1 | - |
| EMBL | AB077997 | BAB83903.1 | - |
| EMBL | AB077998 | BAB83904.1 | - |
| EMBL | AB077999 | BAB83905.1 | - |
| EMBL | AB078000 | BAB83906.1 | - |
| EMBL | AB078001 | BAB83907.1 | - |
| EMBL | AB078002 | BAB83908.1 | - |
| EMBL | AB078003 | BAB83909.1 | - |
| EMBL | AB078004 | BAB83910.1 | - |
| EMBL | BA000002 | BAA79030.1 | - |
| PIR | D72766 | D72766. | |
| HSSP | Q06609 | 1N0W | |
| GenomeReviews | BA000002_GR | APE0119.1 | |
| BioCyc | APER56636:APE0119-MONOMER | -.1 | |
| HAMAP | MF_00348 | - | 1. |
| InterPro | IPR003593 | AAA_ATPase. | |
| InterPro | IPR001553 | RecA_bac. | |
| InterPro | IPR011938 | Recomb_radA. | |
| PRINTS | PR00142 | RECA. | |
| ProDom | PD000229 | RecA | 1. |
| SMART | SM00382 | AAA | 1. |
| TIGRFAMs | TIGR02236 | recomb_radA | 1. |
| PROSITE | PS50162 | RECA_2 | 1. |
| PROSITE | PS50163 | RECA_3 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA recombination; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=OH1, OH2, OH3, TB1, TB2, TB3, TB4, TB5, TB6, TB7, and TB8;
RA Nomura N., Morinaga Y., Kogishi T., Kim E., Sako Y., Uchida A.;
RT "Heterogeneous yet partially similar introns reside in identical
RT positions of the rRNA genes in natural isolates of the archaeon
RT Aeropyrum pernix.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K1;
RX MEDLINE=99310339; PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y.,
RA Jin-no K., Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H.,
RA Hosoyama A., Fukui S., Nagai Y., Nishijima K., Nakazawa H.,
RA Takamiya M., Masuda S., Funahashi T., Tanaka T., Kudoh Y.,
RA Yamazaki J., Kushida N., Oguchi A., Aoki K., Kubota K., Nakamura Y.,
RA Nomura N., Sako Y., Kikuchi H.;
RT "Complete genome sequence of an aerobic hyper-thermophilic
RT crenarchaeon, Aeropyrum pernix K1.";
RL DNA Res. 6:83-101(1999).
Feature:
CHAIN 1 319 DNA repair and recombination protein
radA.
/FTId=PRO_0000150088.
NP_BIND 111 118 ATP (Potential).
VARIANT 5 5 K -> N (in strain: TB2).
VARIANT 5 5 K -> Q (in strain: TB1).
VARIANT 58 58 I -> T (in strain: OH3).
VARIANT 144 144 V -> I (in strain: OH1, OH2, OH3, TB1,
TB2, TB3, TB4, TB5, TB6, TB7 and TB8).
VARIANT 201 201 K -> R (in strain: OH2).
VARIANT 214 214 A -> V (in strain: OH3).
VARIANT 286 286 S -> G (in strain: TB1).
VARIANT 289 289 N -> D (in strain: OH3).
VARIANT 289 289 N -> S (in strain: TB2).
VARIANT 306 306 T -> A (in strain: TB6).
Comments:
-!- FUNCTION: Involved in DNA repair and in homologous recombination.
Binds and assemble on single-stranded DNA to form a nucleoprotein
filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes
DNA strand exchange between homologous DNA molecules (By
similarity).
-!- SIMILARITY: Belongs to the eukaryotic recA-like protein family.
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Sequence length: 319
MGEDKREIKD ITDLPGVGPT TAQKLMEAGY TTLEAIAAAT PQEVSQATGI PILTAQKIVD
AAREALNIDF KTAYDLKIES MNIKKITTGS RNLDELLGGG IETKTITELF GEFGSGKTQI
CHQLSVNVQL PEDKGGLEGK AVYVDTEGTF RWERIEQMAR GVGLDPDEVM KNIYWIRAIN
SHHQIAIVDK LFTMVKNDNI KLVVVDSVTS HFRAEFPGRE NLAMRQQLLN RHLHQLMRLA
DIFNVAVVIT NQVMARPDVF YGDPTQAVGG HVLGHAPGVR VYLKKSRGNK RIARVVDAPH
LPEGETVFAI TEWGIRDPE