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Description:
DNA mismatch repair protein mutH (Methyl-directed mismatch repairprotein).
Molecular weight: 25438
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
13-APR-2004, integrated into UniProtKB/Swiss-Prot.
01-MAR-2002, sequence version 1.
07-MAR-2006, entry version 20.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTH_SALTI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL627277 | CAD02830.1 | - |
| EMBL | AE014613 | AAO70468.1 | - |
| SMR | Q8Z410 | 6-229.1 | |
| GenomeReviews | AL513382_GR | STY3148.1 | |
| GenomeReviews | AE014613_GR | t2914.1 | |
| BioCyc | SENT209261:T2914-MONOMER | -.1 | |
| BioCyc | SENT90370:STY3148-MONOMER | -.1 | |
| HAMAP | MF_00759 | - | 1. |
| InterPro | IPR004230 | MutH. | |
| Pfam | PF02976 | MutH | 1. |
| TIGRFAMs | TIGR02248 | mutH_TIGR | 1. |
Keywords:
Complete proteome; DNA damage; DNA repair; Endonuclease; Hydrolase; Nuclease.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX MEDLINE=21534947; PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA Whitehead S., Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella
RT enterica serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ty2 / ATCC 700931;
RX MEDLINE=22531367; PubMed=12644504;
RX DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT and CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
Feature:
CHAIN 1 231 DNA mismatch repair protein mutH.
/FTId=PRO_0000198672.
Comments:
-!- FUNCTION: Sequence-specific endonuclease that cleaves unmethylated
GATC sequences. It is involved in DNA mismatch repair (By
similarity).
-!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
-!- SIMILARITY: Belongs to the mutH family.
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Sequence length: 231
MSALCPLLTP PASEALLLAQ ARQLSGYTLG ELAVMAGITT PKDLKRDKGW IGVLLEIWLG
ASAGSKPEQD FAALGVELKT IPVDSLGRPL ETTFVCVAPL TGNSGVTWET SHVRHKLKRV
LWVPVEGDRS IPLAERRVGS PLLWSPSEEE DRQLRLDWEE LMDMIVLGQV ERITARHGEV
LQLRPKAANA RALTEAIGAR GEPILTLPRG FYLKKNFTQA LLARHFLLQN P