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Description:
DNA mismatch repair protein mutS.
Molecular weight: 95407
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 ) mismatch repair( GO:0006298 )
Important dates:
01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2005, sequence version 1.
07-MAR-2006, entry version 7.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein MUTS_SALTI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL627276 | CAD06015.1 | - |
| EMBL | AE014613 | AAO70369.1 | - |
| HSSP | P23909 | 1NG9 | |
| SMR | P0A1Y1 | 7-802.1 | |
| GenomeReviews | AL513382_GR | STY3033.1 | |
| GenomeReviews | AE014613_GR | t2810.1 | |
| HAMAP | MF_00096 | - | 1. |
| InterPro | IPR005748 | MutS1. | |
| InterPro | IPR000432 | MutS_C. | |
| InterPro | IPR007860 | MutS_II. | |
| InterPro | IPR007696 | MutS_III. | |
| InterPro | IPR007861 | MutS_IV. | |
| InterPro | IPR007695 | MutS_N. | |
| PANTHER | PTHR11361:SF23 | MutS.1 | 1. |
| Pfam | PF01624 | MutS_I | 1. |
| Pfam | PF05188 | MutS_II | 1. |
| Pfam | PF05192 | MutS_III | 1. |
| Pfam | PF05190 | MutS_IV | 1. |
| Pfam | PF00488 | MutS_V | 1. |
| ProDom | PD001263 | MutS_C | 1. |
| SMART | SM00534 | MUTSac | 1. |
| SMART | SM00533 | MUTSd | 1. |
| TIGRFAMs | TIGR01070 | mutS1 | 1. |
| PROSITE | PS00486 | DNA_MISMATCH_REPAIR_2 | 1. |
Keywords:
ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX MEDLINE=21534947; PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA Whitehead S., Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella
RT enterica serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ty2 / ATCC 700931;
RX MEDLINE=22531367; PubMed=12644504;
RX DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT and CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
Feature:
CHAIN 1 855 DNA mismatch repair protein mutS.
/FTId=PRO_0000115131.
NP_BIND 616 623 ATP (Potential).
Comments:
-!- FUNCTION: This protein is involved in the repair of mismatches in
DNA. It is possible that it carries out the mismatch recognition
step. This protein has a weak ATPase activity (By similarity).
-!- SIMILARITY: Belongs to the DNA mismatch repair mutS family.
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Sequence length: 855
MNESFDKDFS NHTPMMQQYL KLKAQHPEIL LFYRMGDFYE LFYDDAKRAS QLLDISLTKR
GASAGEPIPM AGIPHHAVEN YLAKLVNQGE SVAICEQIGD PATSKGPVER KVVRIVTPGT
ISDEALLQER QDNLLAAIWQ DGKGYGYATL DISSGRFRLS EPADRETMAA ELQRTNPAEL
LYAEDFAEMA LIEGRRGLRR RPLWEFEIDT ARQQLNLQFG TRDLVGFGVE NASRGLCAAG
CLLQYVKDTQ RTSLPHIRSI TMERQQDSII MDAATRRNLE ITQNLAGGVE NTLAAVLDCT
VTPMGSRMLK RWLHMPVRNT DILRERQQTI GALQDTVSEL QPVLRQVGDL ERILARLALR
TARPRDLARM RHAFQQLPEL HAQLETVDSA PVQALRKKMG DFAELRDLLE RAIIDAPPVL
VRDGGVIAPG YHEELDEWRA LADGATDYLD RLEIRERERT GLDTLKVGYN AVHGYYIQIS
RGQSHLAPIN YVRRQTLKNA ERYIIPELKE YEDKVLTSKG KALALEKQLY DELFDLLLPH
LADLQQSANA LAELDVLVNL AERAWTLNYT CPTFTDKPGI RITEGRHPVV EQVLNEPFIA
NPLNLSPQRR MLIITGPNMG GKSTYMRQTA LIALLAYIGS YVPAQNVEIG PIDRIFTRVG
AADDLASGRS TFMVEMTETA NILHNATENS LVLMDEIGRG TSTYDGLSLA WACAENLANK
IKALTLFATH YFELTQLPEK MEGVANVHLD ALEHGDTIAF MHSVQDGAAS KSYGLAVAAL
AGVPKEVIKR ARQKLRELES ISPNAAATQV DGTQMSLLAA PEETSPAVEA LENLDPDSLT
PRQALEWIYR LKSLV