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Description:
Cell division inhibitor.
Molecular weight: 19013
View which proteins in this organism that is involved with DNA Repair;
classified after biological processes (using data from the GOA project):
DNA repair( GO:0006281 )
Important dates:
15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
07-MAR-2006, entry version 5.
Phylogenetic order:
Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Salmonella.
To calculate the pI (Isoelectric point - the pH where a protein has a neutral charge),
go to this page and enter the protein ID (e.g 3MG_ECOLI): http://us.expasy.org/tools/pi_tool.html
Links to references in other databases for protein SULA_SALTI:
| Database | Pointer | Add. info#1 | Add. info#2 |
| EMBL | AL627269 | CAD08197.1 | - |
| EMBL | AE014613 | AAO69467.1 | - |
| GenomeReviews | AL513382_GR | STY1092.1 | |
| GenomeReviews | AE014613_GR | t1849.1 | |
| InterPro | IPR004596 | SulA. | |
| Pfam | PF03846 | SulA | 1. |
| TIGRFAMs | TIGR00623 | sula | 1. |
Keywords:
Cell cycle; Cell division; Complete proteome; DNA damage; DNA repair; Inner membrane; Membrane; Septation; SOS response.
References:
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX MEDLINE=21534947; PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P.,
RA Cronin A., Davis P., Davies R.M., Dowd L., White N., Farrar J.,
RA Feltwell T., Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K.,
RA Krogh A., Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C.,
RA Quail M.A., Rutherford K.M., Simmonds M., Skelton J., Stevens K.,
RA Whitehead S., Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella
RT enterica serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ty2 / ATCC 700931;
RX MEDLINE=22531367; PubMed=12644504;
RX DOI=10.1128/JB.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J.,
RA Burland V., Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2
RT and CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
Feature:
CHAIN 1 169 Cell division inhibitor.
/FTId=PRO_0000072308.
REGION 31 149 Conserved region.
REGION 160 169 Lon protein binding site (Probable).
Comments:
-!- FUNCTION: SulA is a component of the SOS system and an inhibitor
of cell division. Accumulation of sulA causes rapid cessation of
cell division and the appearance of long, non-septate filaments.
The expression of sulA is repressed by the lexA protein. FtsZ
seems to be the target of sulA (By similarity).
-!- SUBCELLULAR LOCATION: Bacterial cell inner membrane (By
similarity).
-!- MISCELLANEOUS: The N-terminus of the sulA protein might be
involved in recognizing the cell division apparatus (By
similarity).
-!- SIMILARITY: Belongs to the sulA family.
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Sequence length: 169
MYTSGYANRS SSFPTTTHNA ARTATENAAA GLVSEVVYHE DQPMMAQLLL LPLLRQLGQQ
SRWQLWLTPQ QKLSREWVQS SGLPLTKVMQ ISQLAPRHTL ESMIRALRTG NYSVVIGWMT
EELTEEEHAS LVEAAKVGNA VGFIMRPVRA HALPRRQHSG LKIHSNLYH